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Huang Jin-zhu, Zhang Yan-zi, Yang Cui-yu, Zhang Ai-sha, Sui Xiao-lu, Xu Yun-peng, Xie Ting-fei, Chen Ji-hong. Role of tubular cell-derived exosomes in renal ischemia reperfusion injury[J]. Journal of Clinical Nephrology, 2024, 24(11): 946-950. DOI: 10.3969/j.issn.1671-2390.2024.11.009
Citation: Huang Jin-zhu, Zhang Yan-zi, Yang Cui-yu, Zhang Ai-sha, Sui Xiao-lu, Xu Yun-peng, Xie Ting-fei, Chen Ji-hong. Role of tubular cell-derived exosomes in renal ischemia reperfusion injury[J]. Journal of Clinical Nephrology, 2024, 24(11): 946-950. DOI: 10.3969/j.issn.1671-2390.2024.11.009
shu

Role of tubular cell-derived exosomes in renal ischemia reperfusion injury

  • 1.

    Second Affiliated Hospital, Shenzhen University(Department of Nephrology, People's Hospital of Baoan District), Shenzhen 518000, China

  • 2.

    Baoan Shenzhen Clinical Medical School of Guangdong Medical University，Shenzhen 518000,China

Funds: Shenzhen Baoan District Science and Technology Plan Basic Research Project(2021JD288)；Shenzhen Baoan District High-level Talent Innovation Project
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    • Abstract

  • Renal ischemia reperfusion injury refers to a pathophysiological phenomenon that aggravates the degree of renal injury due to the restoration of blood supply after transient ischemia of renal tissue. It has been found that renal tubular cell-derived exosomes alleviate renal ischemia reperfusion injury through anti-inflammatory, antioxidant, inhibition of apoptosis, promotion of tissue regeneration and activation of autophagy . This review will discuss the protective effect of tubular cell-derived exosomes on renal ischemia reperfusion injury, in order to provide a theoretical basis for the clinical diagnosis, treatment and early prevention of renal ischemia reperfusion injury.

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