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TANG Wei. Diagnostic value of combined detection of five biochemical indexes in early diabetic nephropathy[J]. Journal of Clinical Nephrology, 2017, 17(10): 614-617. DOI: 10.3969/j.issn.1671-2390.2017.10.009
Citation: TANG Wei. Diagnostic value of combined detection of five biochemical indexes in early diabetic nephropathy[J]. Journal of Clinical Nephrology, 2017, 17(10): 614-617. DOI: 10.3969/j.issn.1671-2390.2017.10.009

Diagnostic value of combined detection of five biochemical indexes in early diabetic nephropathy

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  • Received Date: December 06, 2016
  • Rev Recd Date: September 20, 2017
  • Available Online: May 11, 2023
  • Published Date: October 27, 2017
  • Objective To investigate the diagnostic value of combined detection of serum cystatin C (Cys-C), homocysteine (Hcy), hypersensitive C-reactive protein (hs-CRP), urine β2 microglobulin (U-β2MG) and urinary albumin (UAlb) in early diabetic nephropathy (DN).Methods From January 2012 to May 2016, 48 cases of early DN admitted to our hospital were selected as the observation group, and according to the proportion of 1:1, 48 cases of diabetes mellitus (DM) without DN served as control group. In control group, glomerular filtration rate was normal, and color ultrasound examination displayed normal kidney morphology and size. Within 24 h after admission, 3 ml fasting venous blood was taken out for detection of serum Cys-C, Hcy, hs-CRP, U-β2MG and UAlb after centrifugation. U-β2MG and Cys-C were detected by immune turbidimetry, Hcy by enzymatic method, and hs-CRP and UAlb by immune scattering turbidity method according to the instructions.Results After admission, serum Cys-C[(1.16±0.24) vs. (0.93±0.20) mg/L, t=5.161], hs-CRP[(7.1±2.9) vs. (4.4±2.7) mg/L, t=4.730], Hcy[(22.20±3.95) vs. (15.26±3.55) mg/L, t=9.047], U-β2MG[(0.526±0.110) vs. (0.407±0.136) mg/L, t=4.700] and UAlb[(42.8±6.5) vs. (10.4±3.2) mg/L, t=31.022] in the observation group were significantly higher than those in the control group (P<0.01 for all). The positive rates of serum Cys-C, hs-CRP, Hcy, U-β2MG and UAlb in the observation group were 84.3%, 78.6%, 78.5%, 89.2% and 91.2%, respectively. The positive rate of combined detection was 100%, and the positive rate was improved by combined detection.Conclusions The serum Cys-C, hs-CRP, Hcy, U-β2MG and UAlb are sensitive, accurate, simple and reliable indicators of early renal function damage in DM patients. It can be used in early diagnosis of DN, and it is worthy of clinical popularization and application.
  • [1]
    Sujanitha V, Sivansuthan S, Selvakaran P, et al.Overweight,obesity and chronic complications of diabetes mellitus in patients attending Diabetic Centre,Teaching Hospital,Jaffna,Sri Lanka[J].Ceylon Med J, 2015, 60(3):94-96.
    [2]
    Li S, Guo S, He F, et al.Prevalence of diabetes mellitus and impaired fasting glucose,associated with risk factors in rural kazakhadults in xinjiang,china[J].Int J Environ Res Public Health, 2015, 12(1):554-565.
    [3]
    Liang S, Li Q, Zhu HY, et al. Clinical factors associated with the diagnosis and progression of diabetic nephropathy[J]. Cell BiochemBiophys, 2014, 70(1):9-15.
    [4]
    Titan SM, Vieira JMJr, Dominguez WV, et al. Urinary MCP-1 and RBP:independent predictors of renal outcome in macroalbuminuricdiabetic nephropathy[J]. J Diabetes Complications, 2012, 26(6):546-553.
    [5]
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2013年版)[J]. 中国医学前沿杂志(电子版), 2015, 7(3):26-89.
    [6]
    中华医学会糖尿病学分会微血管并发症学组. 糖尿病肾病防治专家共识(2014年版)[J]. 中华糖尿病杂志, 2014, 6(11):792-801.
    [7]
    Currie G, Mckay G, Delles C. Biomarkers in diabetic nephropathy:present and future[J]. World J diabetes, 2014, 5(6):763-776.
    [8]
    Najafian B, Fogo AB, Lusco MA, et al. AJKD Atlas of Renal Pathology:Diabetic Nephropathy[J]. Am J Kidney Dis, 2015, 66(5):e37-38.
    [9]
    López-Revuelta K, Abreu AA, Gerrero-Márquez C, et al. Diabetic nephropathy without diabetes[J]. J Clin Med, 2015, 4(7):1403-1427.
    [10]
    Bentata Y, Haddiya I, Latrech H, et al. Progression of diabetic nephropathy,risk of end-stage renal disease and mortality in patientswith type-1 diabetes[J]. Saudi J Kidney Dis Transpl, 2013, 24(2):392-402.
    [11]
    Suzuki H, Kikuta T, Inoue T, et al. Time to re-evaluate effects ofrenin-angiotensin system inhibitors on renal and cardiovascularoutcomes in diabetic nephropathy[J]. World J Nephrol, 2015, 4(1):118-126.
    [12]
    Aulin J, Siegbahn A, Hijazi Z, et al. Interleukin-6 and C-reactive proteinand risk for death and cardiovascular events in patients with atrial fibrillation[J]. Am Heart J, 2015, 170(6):1151-1160.
    [13]
    Shlipak MG, Mattes MD, Peralta CA. Update oncystatin C:incorporation into clinical practice[J]. Am J Kidney Dis, 2013, 62(3):595-603.
    [14]
    Togashi Y, Miyamoto Y. Urinarycystatin C as a biomarker for diabeticnephropathy and its immunohistochemical localization in kidney in Zucker diabetic fatty(ZDF)rats[J]. Exp Toxicol Pathol, 2013, 65(5):615-622.
    [15]
    Ruan ZB, Zhu L, Yin YG, et al. Cystatin C, N-terminal probrainnatriuretic peptides and outcomes in acute heart failure with acute kidney injury in a 12-month follow-up:insights into the cardiorenal syndrome[J].J Res Med Sci, 2014, 19(5):404-409.
    [16]
    朱圣军, 汪骅. 多项生化检测指标对早期糖尿病肾病的诊断价值[J]. 实验与检验医学, 2015, 33(4):503-505.
    [17]
    邱军. 胱抑素C、同型半胱氨酸和β2微球蛋白在糖尿病肾病早期的检测价值[J]. 糖尿病新世界, 2016, 19(18):49-50.
    [18]
    王永, 吕高荣. 超敏C反应蛋白测定在慢性阻塞性肺疾病急性加重期的临床意义[J]. 中华全科医学,2013,11(6):881-883.
    [19]
    Koenig W. High-sensitivity C-reactive proteinand atherosclerotic disease:from improved risk predictionto risk-guided therapy[J]. Int J Cardiol, 2013, 168(6):5126-5134.
    [20]
    Shelbaya S, Amer H, Seddik S, et al. Study of the role of interleukin-6 and highly sensitive C-reactive protein in diabeticnephropathy in type 1 diabetic patients[J]. Eur Rev Med Pharmacol Sci, 2012, 16(2):176-182.
    [21]
    Stevens PE,Levin A. Evaluation and management of chronic kidney disease:synopsis of the kidney disease:improving global outcomes 2012 clinical practice guideline[J].Ann Intern Med, 2013, 158(11):825-830.
    [22]
    Juraschek SP, Coresh J, Inker LA, et al. Comparison of Serum Concentrations of β-Trace Protein,β2-Microglobulin,Cystatin C,and Creatinine in the US Population[J]. Clin J Am SocNephrol, 2013, 8(4):584-592.
    [23]
    Ikeda M, Moriguchi J, Sakuragi S, et al. Association of past diseases with levels of cadmium and tubular dysfunction markers in urine of adult women in non-polluted areas in Japan[J]. Int Arch OccupEnvironHealth, 2013, 86(3):343-355.
    [24]
    赵翠霞, 蔡武全, 闫龙. 胱抑素C、尿微量白蛋白及β2微球蛋白的检测对糖尿病肾病早期诊断的价值探讨[J]. 现代诊断与治疗, 2014, 25(18):4225-4226.
    [25]
    王诚, 余红岚, 何伶俐. 胱抑素C、尿β2-MG及mALB/Cr联合检测早期诊断糖尿病肾病的临床意义[J]. 山东医药, 2014, 54(21):58-60.
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