Application of serum levels of SAA,CysC,ACR and IL-19 in the diagnosis of type 2 diabetic nephropathy

Objective To explore the diagnostic values of serum amyloid A(SAA), Cystatin C(CysC), albumin-to-creatinine ratio(ACR) and interleukin-19(IL-19) for type 2 diabetic nephropathy(DN). Methods From October 2017 to October 2020, a total of 108 type 2 diabetics were selected as research subjects. According to the absence and presence of DN, they were divided into two groups of diabetic kidney disease(DKD). Fifty healthy subjects of similar ages receiving routine physical examination were designated as control group to compare the expression levels of SAA, CysC, ACR and IL-19. Results Three groups were significantly different in serum levels of SAA, CysC, ACR and IL-19(P<0.05). Inter-group comparison indicated that DKD group and diabetics had higher expression levels of SAA, CysC, ACR and IL-19 than control group(P<0.05) and serum parameters were higher in DKD group than diabetes group(P<0.05);DKD group had significant differences in serum parameters of patients with varying kidney injury stages(P<0.05). With advancing stages of renal injury, the expression levels of SAA, CysC, ACR and IL-19 gradually spiked(P<0.05);correlation analysis of various serum parameters hinted at a significant positive correlation(P<0.05);the diagnostic accuracy rates of SAA, CysC, ACR, and IL-19 were 65.48%, 76.58%, 73.81% and 69.62% respectively. All were significantly lower than a combined detection rate of 92.41%(P<0.05). Conclusion Serum levels of SAA, CysC, ACR and IL-19 can effectively achieve an early diagnosis of type 2 DN. It is closely correlated to with the degree of renal damage and combined detection of various parameters offers a high diagnostic accuracy rate.