Clinicopathological features of 71 patients with amyloidosis nephropathy

Objective To explore the clinicopathological features of patients with amyloidosis nephropathy to provide more rationales for clinical diagnosis and treatment.Methods From December 1997 to December 2019,clinicopathological data were retrospectively reviewed for 71 patients with amyloidosis diagnosed by renal biopsy.Results The mean age was(57.2±9.9)years,71.8% were aged 50 to 69 years and male-to-female ratio was 1.7∶1.The age and hemoglobin levels of males were higher than those of females.And the differences were statistically significant(P<0.05).Hemoglobin and serum calcium in patients with higher serum creatinine(Scr)were significantly lower(P<0.05)while urea nitrogen,cystatin C,β₂-microglobulin and uric acid were significantly higher than those with normal creatinine(P<0.05).In a declining order,amyloid was deposited in glomerular mesangial area(96.2%),capillary wall(28.3%),interstitial small vessel wall(47.2%),tubules(15.1%),renal interstitium(5.7%)and subendothelium(1.9%).In group of higher Scr,the rates of amyloid deposition were both higher in glomeruli(P=0.032)and tubular atrophy >10%(P=0.024).However,no significant difference existed in clinicopathological parameters between patients with nephrotic-range proteinuria and non-nephrotic-range proteinuria.Conclusion Amyloidosis nephropathy occurs predominantly in middle-aged and elderly males.Glomerular damage is common in patients with amyloidosis nephropathy.And the degree of glomerular amyloidosis in renal tissue is associated with renal insufficiency rather than the level of urinary protein.