Summary of research advances on the correlation between chronic kidney disease and gastrointestinal microbiome

The incidence of chronic kidney disease(CKD)in China has remained elevated and it shows an annually rising trend.However,no radical cure is not currently available.Exploring the risk factors of CKD is a research focus of nephrology.It is generally accepted that the change of intestinal flora was correlated with the development of CKD.And micro-ecological balance of gut might impact upon human health.However,owing to an impairment of intestinal function barrier and an alteration of intestinal flora,an accumulation of gut derived toxin gradually induced a continuous deterioration of CKD.This review was intended to describe the relativity between CKD and intestinal flora and explore the possibility of modulating intestinal flora as a new therapeutic target for CKD.