Expressions of LncRNA HOTAIR and VEGF in adrenal malignant tumors and their prognostic significance

Objective To explore the expression levels of long non-coding RNAHOX transcript antisense intergenic RNA(LncRNAHOTAIR)and vascular endothelial growth factor(VEGF)in patients with adrenal malignant tumor,and analyze their prognostic relationship.Methods From January 2014 to January 2017,167 cases of adrenal gland specimens were selected.The expression levels of HOTAIR and VEGF mRNA were detected by real-time fluorescent quantitative PCR(qRT-PCR).Pearson’s method was employed for analyzing the correlation between HOTAIR and VEGF.And Kaplan-Meier method was applied for evaluatimg the relationship between HOTAIR,VEGF mRNA expression levels and survival of patients with adrenal malignant tumor.In addition,COX method was utilized for analyzing the prognostic factors of patients with adrenal malignant tumor.Results Compared with those in benign adrenal tissues,the relative expression levels of HOTAIR and VEGF mRNA were higher in malignant adrenal tumors(P<0.05).HOTAIR was positively correlated with VEGF(r=0.739,P<0.05).The relationship between HOTAIR,VEGF mRNA and clinicopathological features of adrenal tumors showed that HOTAIR and VEGF mRNA were correlated with distant metastasis(P<0.05),but not with age,gender,tumor diameter,single or multiple tumors(P>0.05).The mean survival time of adrenal tumor patients with low HOTAIR expression was(32.09±0.92)months.It was significantly longer than(21.64±1.49)months of adrenal tumor patients with high HOTAIR expression(P<0.05);The mean survival time of adrenal tumor patients with low VEGF mRNA expression was(31.81±0.97)months and it was significantly longer than(22.37±1.47)months of adrenal tumor patients with high VEGF mRNA expression(P<0.05).Multivariate analysis indicated that distant metastasis,high expressions of HOTAIR and VEGF were independent risk factors for poor prognosis of patients with adrenal tumors.Conclusions The expressions of LncRNA HOTAIR and VEGF are up-regulated in adrenal malignant tumors.Both may be biomarkers of poor prognosis in patients with adrenal tumors.