Risk factors of hyperuricemia in patients with non-dialytic chronic kidney disease

Objective To explore the prevalence and risk factors of hyperuricemia(HUA)in patients with non-dialytic chronic kidney disease(ND-CKD).Methods Clinical data were collected for 540 patients with confirmed ND-CKD between January 2015 and December 2019.They were divided into HUA group(n=295)and non-HUA group(n=245)according to the definition of hyperuricemia(male>420 μmol/L,female>360 μmol/L).Clinical data of two groups were compared.Logistic regression analysis was employed for identifying the risk factors of HUA in ND-CKD patients.Results The prevalence of HUA was 54.6%.And the incidence of HUA in CKD stage 1~5 patients was 31.7%,50.5%,58.7%,64.3% and 76.3%.Multivariate stepwise logistic regression analysis revealed that male(OR=1.583,95%CI 1.018~2.461,P<0.05),CKD staging(OR=1.501,95%CI 1.230~1.832,P<0.01),hypertension(OR=1.632,95%CI 1.020~2.611,P<0.05),body mass index(OR=1.111,95%CI 1.042~1.186,P<0.01),blood phosphorus(OR=5.947,95%CI 2.589~13.658,P<0.01)and age(OR=0.971,95%CI 0.957~0.985,P<0.01)were the independent risk factors of HUA in ND-CKD patients.Conclusions The incidence of HUA rises gradually with a higher stage of CKD.Paying close attention to the occurrence of HUA in ND-CKD patients and taking early interventions risk factors may delay the progression of disease.