Hemoglobin level and its related factors in patients undergoing peritoneal dialysis

Objective To explore the hemoglobin level and its related factors in patients on peritoneal dialysis(PD).Methods From May 1,2019 to September 30,2019,280 patients initiated PD and continued it for ≥ 3 months with complete follow-up data.The percentage of patients with Hb levels reaching the guideline target(Hb ≥ 110 g/L) and associated factors of Hb were analyzed. Results Mean Hb concentration was(106.08±20.42) g/L and the rate of target-attaining for hemoglobin 40.36%.The rate of targets for ferroprotein(200-500 μg/L),transferrin saturation(≥ 20%) were 76.78% and 38.95%.Compared with non target-hemoglobin group,target-hemoglobin group had significant statistical differences of dialytic duration,dose of recombinant human erythropoietin,subjective global assessment,serum phosphate,blood calcium,serum albumin,serum iron,ransferrin saturation,cholesterol level and residual renal function(P<0.05).Compared with high transport group,high average transport and low average transport groups had statistically different level of hemoglobin.Univariate logistic regression analysis revealed that duration of dialysis therapy >1 year,subjective global assessment,serum albumin<35 g/L,parathyroid hormone >300 ng/L,blood calcium >2.5 mmol/L,serum iron<10.6 μmol/L and transferrin saturation<20%.Multivariate Logistic regression analysis revealed that duration of dialysis therapy ≥ 5 years,serum albumin<35 g/L,intact parathyroid hormone >800 ng/L,serum iron<10.6 μmol/L and transferrin saturation<20% were independent risk factors of anemia in PD patients. Conclusion Advanced dialysis age,hypoalbuminemia,hyperparathyroidism and iron deficiency are independent influencing factors of hemoglobin level in PD patients.