Research advances of ferroptosis in the pathogenesis of diabetic kidney disease

Ferroptosis is a novel mode of cell death discovered in recent years. Unlike necrosis, apoptosis or autophagy, ferroptosis is the result of iron-dependent lipid peroxidation accumulation. A growing number of studies have demonstrated that the pathogenesis of diabetic kidney disease （DKD） is correlated closely with ferroptosis, involving abnormal iron metabolism, an accumulation of lipid peroxidation, an inhibition of glutathione peroxidase 4 activity and mitochondrial dysfunction. This review summarized the characteristics of ferroptosis, the key signaling factors regulating ferroptosis, the relationship between key signaling pathways and DKD and the latest researches of targeting ferroptosis in the treatment of DKD, aiming to provide references for clinical prevention and treatment of DKD.