Cui Jie-yuan, Zhang Lei, Yuan Xiao-ying, Han Pei-tong, Zhang Dong-feng, Li Chun-zhen. Recent advances of hereditary focal segmental glomerulosclerosis[J]. Journal of Clinical Nephrology, 2023, 23(5): 416-421. DOI: 10.3969/j.issn.1671-2390.2023.05.011
    Citation: Cui Jie-yuan, Zhang Lei, Yuan Xiao-ying, Han Pei-tong, Zhang Dong-feng, Li Chun-zhen. Recent advances of hereditary focal segmental glomerulosclerosis[J]. Journal of Clinical Nephrology, 2023, 23(5): 416-421. DOI: 10.3969/j.issn.1671-2390.2023.05.011
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    Recent advances of hereditary focal segmental glomerulosclerosis

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    • Focal segmental glomerulosclerosis (FSGS) is one of the most common pathological type of nephrotic syndrome. It is caused by podocyte injury from many factors. There are at least 10 single gene diseases of FSGS due to mutations in ACTN4, TRPC6, CD2AP, APOL1, INF2, MYO1E, PAX2, ANLN, CRB2 and LMX1B. FSGS is also present in some hereditary glomerular diseases and tubulo-interstitial diseases. The review summarized the genes, phenotypes and treatments of FSGS.
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