Clinical significance of bone turnover biomarkers in patients with chronic kidney disease

Chronic kidney disease-mineral and bone disorder(CKD-MBD) is one of the most common complications of chronic kidney disease(CKD).It may cause mineral disorder,osteoporosis,fracture and vascular calcification and affect the prognosis of patients.Thus it is imperative to screen,diagnose and treat CKD-MBD in an early stage.Bone biopsy is not applied extensively due to its invasiveness.Currently a definite diagnosis of CKD-MBD is dependent upon measuring the levels of bone turnover biomarkers(BTMs).Many recent studies have demonstrated that BTMs are valuable for assessing bone turnover and patient prognosis.This review focused upon the clinical significance of BTMs in CKD patients and provided references for clinical diagnosis and prognostic assessment of CKD-MBD.