Relationship between serum 25-(OH) D3 and anti-PLA2R antibody titers in patients with primary membranous nephropathy and the significance of combined detection

Objective To explore the value and clinical significance of serum 25-hydroxy vitamin D325-(OH) D3and anti-phospholipase A2 receptor(PLA2R) antibody titers for predicting treatment responsiveness in patients with primary membranous nephropathy(PMN).Methods A total of 100 PMN patients were selected.Based upon serum 25-(OH) D3 level, they were divided into three groups of normal, declining and deficiency.The correlation between(OH) D3, 24-h urine protein and anti-PLA2R antibody titer in patients and serum 25-(OH) D3 level and anti-PLA2R antibody titer in patients with different treatment responses were compared.Value of combination and anti-PLA2R antibody titers in predicting treatment responsiveness were analyzed.Results The 24 h urine protein(8.07±1.81) g vs (6.28±1.76) g、(4.95±1.10) gand anti-PLA2R antibody titers(30.25±5.76) RU/mL vs (23.96±4.85) RU/mL、(18.43±4.05) RU/mLin deficiency group were higher than those in reduced and normal groups and reduced group(6.28±1.76) g vs (4.95±1.10) g、(23.96±4.85) RU/mL vs (18.43±4.05) RU/mLwas higher than normal group(P<0.05).There was a negative correlation between antibody titers(P<0.05);after treatment, serum 25-(OH) D3 level(23.64±6.95) μg/L vs (18.03±6.17) μg/L、(11.88±3.74) μg/Lin patients with complete remission was higher than that in patients with partial remission and non-remission;patients with partial remission(18.03±6.17) μg/L vs (11.88±3.74) μg/Lwere higher than those in non-remission(P<0.05);Serum anti-PLA2R antibody titers(19.25±3.01) RU/mL vs (24.86±3.25) RU/mL、(41.34±8.44) RU/mLin complete remission patients were lower than those in partial remission and non-remission patients;anti-PLA2R antibody titers(24.86±3.25) RU/mL vs (41.34±8.44) RU/mLin partial remission patients were lower than those in non-remission patients(P<0.001);The area under the curve(AUC) of predicting complete remission in PMN patients was 0.913(95%CI:0.855-0.970) with a sensitivity of 90.91% and a specificity of 79.10%.Conclusion Serum 25-(OH) D3 level is negatively correlated with 24 h urine protein and anti-PLA2R antibody titers in PMN patients.And serum 25-(OH) D3 plus anti-PLA2R antibody titers has a certain value in predicting treatment response in PMN patients.