Research advances of correlations between bone and mineral metabolism disorders and immune dysfunction and infection in chronic kidney disease

Chronic kidney disease(CKD) impairs immune function and renders patients susceptible to infection. The underlying mechanism of impaired immune function is multi-factorial. And mineral and bone disorder(MBD) is also involved. This review systematically summarized the mechanism of MBD biomarkers(vitamin D, fibroblast growth factor 23, parathyroid hormone, calcium & phosphorus) in regulating human immune function and the relationship between metabolic disorders and risk of infection. The potential values of vitamin D in regulating immunity and lowering the risk of infection provided rationales for clinically managing the risk of infection in CKD patients.