Influencing factors of eosinophilia in peripheral blood of maintenance hemodialysis patients and its relationship with prognosis

Objective To explore the influencing factors of eosinophilia in peripheral blood of maintenance hemodialysis patients and examine its relationship with prognosis. Methods From January 1 to January 31, 2018, 114 MHD patients at dialysis center of our hospital were retrospectively selected and divided into two groups of A(>5%) and B(<5%) according to the proportion of eosinophil. The inter-group differences in baseline profiles and laboratory tests were analyzed. They were followed up for 45 months. Logistic model was utilized for examining the factors related to all-cause endpoint events and receiver operating characteristic(ROC) curve for analyzing the predictive efficacy of elevated eosinophil ratio on all-cause endpoint events. Results Significant inter-group differences existed in gender, coronary heart disease, cardiac function grade Ⅲ/Ⅳ, high-sensitivity C-reactive protein, dialysis adequacy (Kt/V), pre-dialysis calcium(Ca), ferritin, parathyroid hormone(iPTH) and all-cause endpoints(P<0.05). After adjusting for various confounding factors, Logistic analysis revealed a significant correlation between all-cause endpoints and elevated proportion of eosinophils(P=0.03, 95%CI 1.013-1.281). The area under the curve(AUC) of predicting all-cause endpoint was 68% with a sensitivity of 68% and a specificity of 74.6%. Conclusion Inflammatory status, iPTH and pre-dialysis calcium are the influencing factors of elevated eosinophil ratio. And elevated eosinophil ratio is an independent risk factor for allcause endpoint events in MHD patients.