Relationships of triglyceride-glucose，triglyceride/high-density lipoprotein，homeostasis model assessment-insulin resistance，apolipoprotein B/apolipoprotein A1，high-sensitivity C-reactive protein and risk of hyperuricemia

Objective To explore the relationship between triglyceride-glucose （TG），triglyceride/high-density lipoprotein （TG/HDL），homeostasis model assessment-insulin resistance （HOMA-IR），Apolipoprotein B/Apolipoprotein A1 （ApoB/ApoA1），high-sensitivity C-reactive protein （hs-CRP） and the risk of hyperuricemia （HUA）.Methods Clinical data from 10，241 respondents of 2009 China Health and Nutritional Survey （CHNS） were reviewed.Various variables were merged and cleaned.They were divided into two groups according to the presence or absence of HUA.Software packages SPSS22.0 and MedCalc 18 were utilized for statistical analyses.Results A total of 9463 subjects were included with an average age of 47.53 years and 1468 cases （15.5%） of HUA were identified.After adjusting covariates by Logistic regression，as compared with Q1 group，the risks of TyG，TG/HDL，HOMA-IR，ApoB/ApoA1，hs-CRP and HUA in Q4 group were 8.19（5.14-13.04），7.73（4.95-12.07），1.94（1.38-2.73），1.49（1.03-2.16） and 2.64（1.80-3.88） respectively.Subgroup analyses indicated that males，age≥40 years，body mass index （BMI） ≥24 kg/m²，smokers，alcoholics and people with diabetes mellitus （DM） and hypertension were at higher risk of HUA.Receiver operating characteristic curve （ROC） analyses revealed that TyG had the highest predictive value for HUA.This trend was noteworthy in individuals of males，age≥40 years and BMI≥24 kg/m².Conclusion TyG offers the highest risk and predictive capability for HUA，followed by TG/HDL，hs-CRP，ApoB/ApoA1 and HOMA-IR.