Correlation between body composition analysis and cognition in maintenance hemodialysis patients

Objective To employ body composition monitor （BCM） to measure body composition in patients with maintenance hemodialysis （MHD） and examine the correlation between measurement results and cognitive function.Methods From May 2019 to December 2019，a total of 106 patients with chronic renal failure （CRF） receiving MHD were selected.Their general clinical data were collected.Various parameters of body composition were analyzed by BCM，including overhydration （OH），fat tissue index （FTI），lean tissue index （LTI），body mass index （BMI），total body water （TBW），extracellular water （ECW） and intracellular water （ICW）.Montreal Cognitive Assessment Scale （MoCA） was employed for assessing cognitive function.Based upon the cognitive function score，they were divided into two groups of normal cognitive function and cognitive dysfunction group.And correlation between body composition and cognitive function was examined.Results Significant inter-group differences existed in age，duration of dialysis，OH/ECW，ECW/H，LTI and ICW （P<0.05）.Multiple linear regression analysis indicated that age （P=0.007），OH/ECW （P=0.044），ECW/H （P=0.001） and LTI （P=0.000） were correlated with cognitive impairment.Conclusion Age，OH/ECW，ECW/H and LTI are significantly associated with cognitive dysfunction in MHD patients.Advanced age，higher levels of OH/ECW and ECW/H and lower level of LTI were accompanied with worse cognition.