Research advances on the pathogenesis of IgA nephropathy

IgA nephropathy is the most common primary glomerular disease in the world. Up to20%-40% of patients develop end-stage renal disease within 20 years after a definite diagnosis of renal biopsy. Current managements of this disease include supportive measures and immunosuppressive therapy.Since an in-depth understanding of its pathogenesis is vital for its effective treatment,researches on the pathogenesis of IgA nephropathy has been a major hotspot in the field of kidney diseases. This review summarized the mainstream theory of "quadruple blow" and focused upon IgA receptors and activated complements in the pathogenesis of IgA nephropathy. It was intended to provide theoretical rationales for further clinical exploring therapeutic targets for IgA nephropathy.