Differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin-like growth factor binding protein 7,neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinase-2 in se

Objective To explore the efficacies of continuous renal replacement(CRRT) versus intermittent hemodialysis(IHD) for urinary insulin-like growth factor binding protein 7(IGFBP-7) and tissue inhibitor of metalloproteinase-2(TIMP-2) and compare the differences in blood levels of neutrophil gelatinase-associated lipocalin(NGAL) in septic patients with acute kidney injury(AKI).Methods From January to September 2019,100 hospitalized septic patients with AKI were divided into two groups of observation and control according to specific treatment mode(n=50 each). Observation group underwent CRRT while control group had IHD. All cardiac function tests were completed and blood biochemical parameters detected during treatment. The inter-group differences of urinary levels of IGFBP-7,TIMP-2 and NGAL were analyzed. For comparing two groups pre/post-treatment,mean arterial pressure(MAP),left ventricular ejection fraction(LVEF),cardiac index(CI),cardiac output(CO),inflammatory factor parameters of C-reactive protein(CRP),white blood count(WBC),procalcitonin(PCT),renal function parameters of blood urea nitrogen(BUN) and serum creatinine(Scr) and differences of APACHE Ⅱ were recorded.Results The recovery time of urinary volume,organ support time,intensive care unit(ICU) stay and incidence rate of cardiovascular events were significantly lower in observation group than those in control group. And the differences had statistical significance(P<0.05). After treatment,LVEF,CI and CO were significantly higher in observation group than those in control group and the differences had statistical significance(P<0.05). CRP,WBC,PCT,BUN,Scr and APACHE II were significantly lower in both groups than thosepre-treatment. And observation group was significantly lower than control group and the differences were statistically significant(P<0.05). The urinary levels of IGFBP-7,TIMP-2 and NGAL were significantly lower in observation group posttreatment than those pre-treatment. All were significantly lower than those in control group and the differences had statistical significance(P<0.05).Conclusions More effective than IHD in the treatment of sepsis with AKI,CRRT can effectively shorten ICU stay and improve the urinary levels of IGFBP-7,TIMP-2 and NGAL. It is worthy of wider clinical applications.