Histone modification in diabetic nephropathy

Diabetic nephropathy(DN) is a clinical syndrome characterized by persistent proteinuria and progressive decline in renal function. It is a typical glomerular disease. The incidence is rising yearly and it has become the most common cause of end-stage renal disease. It is particularly important to elucidate the underlying pathogenesis of DN. A growing body of evidence has demonstrated that the pathogenesis of DN is not only regulated by classical signaling pathways, but also by such epigenetic mechanisms as histone modification, DNA methylation and non-coding RNA. With the continuous discovery of research, the role of histone modification in the pathogenesis of DN has come into spotlightr. This review summarized the role of histone modifications in the pathogenesis of DN and the therapeutic prospects for DN.