Correlation between dyslipidemia and disease activity of lupus nephritis

Objective To explore the correlation between dyslipidemia and lupus nephritis(LN).Methods From January 2016 to January 2019,472 LN patients were retrospectively analyzed.And 212 of them received renal biopsy and 236 healthy people were selected according to a ratio of 2:1.Based upon lupus activity score(SLEDAI),pathological type of LN and blood levels of total cholesterol(TC),total triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were recorded.Analysis of variance and correlation were utilized for examining the correlation between dyslipidemia and disease activity of LN.Results The average levels of blood lipids(TC/TG/HDL-C/LDL-C)in LN patients were higher than those in healthy subjects and the differences in the levels of TC,TG and HDL-C were statistically significant(P<0.01);The levels of TC,TG,LDL-C,SLEDAI and 24-hour LDL-C were higher in LN dyslipidemia group.The incidence rate of total protein 24hUTP,urea nitrogen(BUN),uric acid(UA),D-dimmer and erythrocyte sedimentation rate(ESR)in urine were higher than those in normal lipid group.Estimated glomerular filtration rate(eGFR),LDL-C and albumin(Alb)were lower than those of normal lipid group(P<0.05).Significant differences existed in TC(F=4.839,P=0.008),TG(F=3.105,P=0.046)and LDL-C(F=4.605,P=0.046)among different SLEDAI groups.The levels of TC,TG and LDL-C were significantly higher in severe active group than those in control group(P<0.05).Logistic regression analysis showed that the elevation of TC/TG and the reduction of HDL-C were the risk factors of LN.Pearson’s correlation analysis indicated that the levels of TC,TG and LDL-C were positively correlated with SLEDAI(r>0,P>0.05)while the level of HDL-C negatively correlated with SLEDAI(r<0,P<0.05).Conclusion A significant correlation exists between blood lipid level and SLEDAI in LN patients.Early monitoring of blood lipid level is of great significance for tracking the disease activity of LN patients.