Analysis of the incidence and related factors of insulin resistance in patients with non-diabetic nephropathy

Objective To explore the incidence of insulin resistance(IR) and examine the IR-related factors in patients with non-diabetic chronic kidney disease (CKD).Methods From March 2017 to March 2018,non-diabetic CKD hospitalized patients fulfilling the inclusion criteria were analyzed.And the relevant biochemical parameters were recorded.Results The incidence of IR in CKD1-5 phase was 24.53%,29.76%,28.40%,26.42% and 24.42% respectively and no inter-group statistical difference existed in IR incidence (P>0.05).Correlation analysis indicated that body mass index (BMI),calcium and triglyceride were positively correlated with IR;hemoglobin,iron and total cholesterol were negatively correlated with HOMA-IR.Other parameters were not correlated with IR.Further binary Logistic regression revealed that normal triglyceride (OR=0.360、P=0.001),normal BMI (OR=0.272,P=0.004) and normal hemoglobin level (OR=0.301,P=0.001) were protective factors of IR.Metabolic acidosis (OR=6.264,P=0.025) and 25(OH)₂D₃ deficiency (P=0.004,OR=3.032) were risk factors of IR.Conclusion IR occurs in all stages of CKD.However,no statistical difference exists in the incidence of IR in all stages.No significant difference in IR exists among hemodialysis,abdominal dialysis,non-dialysis and different age groups.Normal triglyceride,normal BMI and normal hemoglobin level are protective factors for IR.And metabolic acidosis and 25(OH)₂D₃deficiency are risk factors for IR.