Impact of blood pressure variability on arteriovenous graft function during hemodialysis

Objective To explore the effect of blood pressure variability(BPV) on the function of arteriovenous graft(AVG) during hemodialysis. Methods Clinical data of maintenance hemodialysis(MHD) AVG patients in December 2017 were reviewed. The major observation parameter was AVG power loss within 1 year after enrollment. Results A total of 49 MHD patients were enrolled. According to whether or not BPV was greater than a median of 17.0, they were divided into two groups of BPV ≥ 17(n=25) and BPV<17(n=24). AVG power loss was 80%(20/25) and 46%(11/24) in BPV ≥ 17 group and BPV<17 group within 1 year of follow-up respectively(P=0.028). Inter-group statistical difference existed in cumulative AVG patency rate at 1 yearHR(95%CI)=2.48(1.18~5.18), P=0.012;multivariate analysis indicated that BPV factorial analysis, hypertension, diabetes mellitus and abnormal hemoglobin level were independent risk factors for AVG power loss. Conclusion During hemodialysis, BPV is an independent risk factor for AVG power loss, especially in patients with diabetes, hypertension and abnormal hemoglobin level. Clinicians should pay close and intervene timely to minimize the occurrence of AVG power loss.