Clinical characteristics and influencing factors of abdominal aorta calcification in maintenance hemodialysis patients

Objective This study is to explore the influencing factors of abdominal aortic calcification and to provide new ideas for the prevention and treatment of vascular calcification in maintenance hemodialysis patients.Methods Seventy patients with maintenance hemodialysis in the blood purification center of the Aerospace Center Hospital were selected as the research objects.The clinical laboratory data of the patients were collected.Kaupplia's semi-quantitative scoring method for abdominal lateral radiographs were used to detect the abdominal aortic calcification scores,For scoring,dialysis patients were divided into control group (calcification score <5 points) and case group (calcification score ≥ 5 points).Multivariate logistic regression analysis was used and ROC curve was established to evaluate the predictive value of each influencing factor for abdominal aortic calcification.Results The average abdominal aortic calcification score of 70 patients was (7.34±6.84) points,including 31 cases in the control group and 39 cases in the case group.The univariate analysis results suggested that the patient group's age,dialysis age,hypersensitive c-reactive protein(hs-CRP),blood calcium and body mass index levels were significantly lower than those in the control group,and the level of high-density lipoprotein was lower than that in the control group,with all statistically significant differences (P<0.05).Correlation analysis and multivariate logistic regression analysis showed that age,increased blood calcium and high-sensitivity C-reactive protein levels were independent risk factors for moderate and severe abdominal aortic calcification in maintenance hemodialysis patients (P<0.05).ROC curve analysis showed that the diagnostic cut-off values of age,blood calcium,and hs-CRP were 60.5 years old,2.21 mmol/L and 1.09 mg/dL,respectively; and sensitivity and specificity were 0.667 and 0.667,0.769 and 0.452,0.897 and 0.677,respectively.When age,blood calcium and hs-CRP were combined for prediction,sensitivity and specificity were 0.872 and 0.677,and the area under the AUC curve was 0.801.Conclusions The incidence of abdominal aortic vascular calcification in maintenance hemodialysis patients is high,with high severity.Age,hs-CRP and hypercalcemia are its independent risk factors.