Progress in pharmacogenetic studies on effect on tacrolimus concentrations

The pharmacokinetic and pharmacodynamic parameters of tacrolimus have big individual differences,and the drug has a narrow treatment window.These are main causes leading to rejection and toxic reactions,and hereditary factors are one of main causes for individual difference of tacrolimus efficacy.In this paper,we review the hereditary factors which affect tacrolimus concentrations,mainly including metabolic enzyme gene polymorphism and dry delivery protein gene polymorphism,so as to provide reference for achievement of clinical individualized treatment with tacrolimus.