• Journals Master List
  • DOAJ
  • 数据库logo
  • EuroPub
ZHANG Zhi-qin, WEI Mao-bi, WANG Bai-ying, CHEN Wei, WU Xiao-yan. The correlation between serum adiponectin and hypoxia-inducible factor-1 in patients with diabetic nephropathy[J]. Journal of Clinical Nephrology, 2020, 20(9): 731-735. DOI: 10.3969/j.issn.1671-2390.2020.09.008
Citation: ZHANG Zhi-qin, WEI Mao-bi, WANG Bai-ying, CHEN Wei, WU Xiao-yan. The correlation between serum adiponectin and hypoxia-inducible factor-1 in patients with diabetic nephropathy[J]. Journal of Clinical Nephrology, 2020, 20(9): 731-735. DOI: 10.3969/j.issn.1671-2390.2020.09.008

The correlation between serum adiponectin and hypoxia-inducible factor-1 in patients with diabetic nephropathy

More Information
  • Received Date: March 02, 2020
  • Available Online: May 11, 2023
  • Published Date: September 27, 2020
  • Objective To investigate the correlation between adiponectin(ADPN) and hypoxia-inducible factor-1(HIF-1α) in the serum of diabetic nephropathy patients and its clinical significance.Methods A total of 65 diabetic nephropathy(DKD) patients admitted to Central South Hospital of Wuhan University from 2019.8.27 to 2019.12.29 were selected. Diagnostic criteria of diabetic nephropathy referred to Expert Consensus on Prevention and Treatment of Diabetic Nephropathy(2014 edition).The control group(CN) consisted of 23 patients with only oblique hernia or intestinal polyps without other symptoms.The diabetic nephropathy group was divided into macroalbuminuria subgroup(10 patients) and microalbuminuria subgroup(37 patients) according to the urinary protein excretion(UAER).The remaining 18 patients were non-albuminuria.The DKD group meeting the criteria of diabetic retinopathy with any stage of chronic kidney disease was included in the retinopathy group.However,since there was also a retinopathy subgroup in the proteinuria group,the cumulative number of retinopathy subgroup was 26 patients.The standard of the macroalbuminuria subgroup was urinary albumin>300 mg/24h or (+++)or above,while the standard of the microalbuminuria subgroup was ualbumin <300 mg/24h or (++)or below.The differences and correlations of serum adiponectin and HIF-1α between the two groups and their subgroups were analyzed to explore their clinical significance.Results Serum adiponectin and HIF-1α levels in the diabetic nephropathy group were higher than those in CN group,and serum adiponectin in the DKD group was 3808 ng/L(3625,4164) vs.CN group 2954 ng/L(2439,3809)(P<0.01);serum HIF-1α in the DKD group was 130.44 ng/L(119.50,143.08) vs.CN group 98.32 ng/L(88.04,117.71)(P<0.01).At the same time,linear regression analysis showed that serum ADPN level was positively correlated with hif-1α,with R correlation coefficient=0.961,slope=26.29,and P<0.01.Moreover,the detection efficiency of serum adiponectin and hif-1 to DKD was 0.747 and 0.776,respectively,and P<0.01.Conclusion Serum adiponectin level is increased and positively correlated with HIF-1α in diabetic nephropathy,and serum adiponectin and HIF-1α may have correlative mechanism worthy of exploration.Serum ADPN may be co-involved in the progression of diabetic nephropathy by relating to hypoxia in the body.
  • [1]
    Markaki A,Psylinakis E,Spyridaki A.Adiponectin and end-stage renal disease[J].Hormones,2016,15(3):345-354.DOI: 10.14310/horm.2002.1698.
    [2]
    Frankenberg ADV,Reis AF,Gerchman F.Relationships between adiponectin levels,the metabolic syndrome,and type 2 diabetes:a literature review[J].Arch Endocrinol Metab,2017,61(6):614-622.DOI: 10.1590/2359-3997000000316.
    [3]
    Shao Y,Lv C,Yuan Q,et al.Levels of serum 25(OH)VD3,HIF-1α,VEGF,vWf,and IGF-1 and their correlation in type 2 diabetes patients with different urine albumin creatinine ratio[J].J Diabetes Res,2016,2016:1925424.DOI: 10.1155/2016/1925424.
    [4]
    Sagar SKD,Zhang CC,Guo Q,et al.Role of expression of endothelin-1 and angiotensin-Ⅱ and hypoxia-inducible factor-1α in the kidney tissues of patients with diabetic nephropathy[J].Saudi J Kidney Dis Transplant,2013,24(5):959-964.DOI: 10.4103/1319-2442.118098.
    [5]
    Wang J,Ye S.Up-regulation of hypoxia inducible Factor-1α in patients with diabetic nephropathy[J].Niger J Clin Pract,2019,22(6):750-753.DOI: 10.4103/njcp.njcp_495_18.
    [6]
    Zhu QQ,Li HB,Xie X,et al.Adiponectin facilitates postconditioning cardioprotection through both AMPK-dependent nuclear and AMPK-independent mitochondrial STAT3 activation[J].Oxidative Med Cell Longev,2020,2020:1-17.DOI: 10.1155/2020/4253457.
    [7]
    Perdicaro DJ,Rodriguez LC,Gambarte TJ,et al.Quercetin attenuates adipose hypertrophy,in part through activation of adipogenesis in rats fed a high-fat diet[J].J Nutr Biochem,2020,79:108352.DOI: 10.1016/j.jnutbio.2020.108352.
    [8]
    Huang HP,Jiang XF,Dong YB,et al.Adiponectin alleviates genioglossal mitochondrial dysfunction in rats exposed to intermittent hypoxia[J/OL].PLoS One,2014,9(10):e109284.DOI: 10.1371/journal.pone.0109284.
    [9]
    Ding WX,Dong YB,Ding N,et al.Adiponectin protects rat heart from left ventricular remodeling induced by chronic intermittent hypoxia via inhibition of TGF-β/smad2/3 pathway[J].J Thorac Dis,2014,6(9):1278-1284.DOI: 10.3978/j.issn.2072-1439.2014.07.44.
    [10]
    中华医学会糖尿病学分会微血管并发症学组.糖尿病肾脏疾病防治专家共识(2014年版)[J].中华糖尿病杂志,2014,6(11):792-801.DOI: 10.3760/cma.j.issn.1674-5809.2014.11.004.
    [11]
    Gupta J,Dominic EA,Fink JC,et al.Association between inflammation and cardiac geometry in chronic kidney disease:findings from the CRIC study[J/OL].PLoS One,2015,10(4):e0124772.DOI: 10.1371/journal.pone.0124772.
    [12]
    Qian Q.Inflammation:a key contributor to the genesis and progression of chronic kidney disease[J].Contributions Nephrol,2017,191:72-83.DOI: 10.1159/000479257.
    [13]
    Locsey L,Seres I,Sztanek F,et al.Relationship between serum paraoxonase and homocysteine thiolactonase activity,adipokines,and asymmetric dimethyl arginine concentrations in renal transplant patients[J].Transplant Proc,2013,45(10):3685-3687.DOI: 10.1016/j.transproceed.2013.10.003.
    [14]
    Jorsal A,Tarnow L,Frystyk J,et al.Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy[J].Kidney Int,2008,74(5):649-654.DOI: 10.1038/ki.2008.201.
    [15]
    Saraheimo M,Forsblom C,Thorn L,et al.Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes[J].Diabetes Care,2008,31(6):1165-1169.DOI: 10.2337/dc07-2306.
    [16]
    Markaki A,Psylinakis E,Spyridaki A.Adiponectin and end-stage renal disease[J].Hormones,2016,15(3):345-354.DOI: 10.14310/horm.2002.1698.
    [17]
    丁文筱,张蔷,葛路遥,等.脂联素对慢性间歇性缺氧所致大鼠胰岛细胞线粒体损伤的作用[J].中华医学杂志,2019,99(18):1380-1384.DOI: 10.3760/cma.j.issn.0376-2491.2019.18.005.
    [18]
    Wang BD,Guo H,Li X,et al.Adiponectin attenuates oxygen-glucose deprivation-induced mitochondrial oxidative injury and apoptosis in hippocampal HT22 cells via the JAK2/STAT3 pathway[J].Cell Transplant,2018,27(12):1731-1743.DOI: 10.1177/0963689718779364.
    [19]
    Ding WX,Cai YP,Wang WJ,et al.Adiponectin protects the kidney against chronic intermittent hypoxia-induced injury through inhibiting endoplasmic reticulum stress[J].Sleep Breath,2016,20(3):1069-1074.DOI: 10.1007/s11325-016-1321-4.
    [20]
    Lee HP,Lin CY,Shih JS,et al.Adiponectin promotes VEGF-A-dependent angiogenesis in human chondrosarcoma through PI3K,Akt,mTOR,and HIF-α pathway[J].Oncotarget,2015,6(34):36746-36761.DOI: 10.18632/oncotarget.5479.
    [21]
    Lai XR,Tong D,Ai XP,et al.Amelioration of diabetic nephropathy in db/db mice treated with Tibetan medicine formula Siwei Jianghuang Decoction Powder extract[J].Sci Rep,2018,8(1):16707.DOI: 10.1038/s41598-018-35148-2.
    [22]
    袁明霞,唐荣,周巧玲,等.冬虫夏草对糖尿病肾脏疾病大鼠肾组织HIF-1α及VEGF表达的影响[J].中南大学学报(医学版),2013,38(5):448-457.DOI: 10.3969/j.issn.1672-7347.2013.05.003
    [23]
    Xu XJ,Chen P,Zheng QL,et al.Effect of pioglitazone on diabetic nephropathy and expression of HIF-1α and VEGF in the renal tissues of type 2 diabetic rats[J].Diabetes Res Clin Pract,2011,93(1):63-69.DOI: 10.1016/j.diabres.2011.03.019.
    [24]
    Boonloh K,Lee ES,Kim HM,et al.Rice bran protein hydrolysates attenuate diabetic nephropathy in diabetic animal model[J].Eur J Nutr,2018,57(2):761-772.DOI: 10.1007/s00394-016-1366-y.
    [25]
    Rudnicki M,Perco P,Enrich J,et al.Hypoxia response and VEGF-A expression in human proximal tubular epithelial cells in stable and progressive renal disease[J].Lab Invest,2009,89(3):337-346.DOI: 10.1038/labinvest.2008.158.
    [26]
    Eckardt KU,Bernhardt W,Willam C,et al.Hypoxia-inducible transcription factors and their role in renal disease[J].Semin Nephrol,2007,27(3):363-372.DOI: 10.1016/j.semnephrol.2007.02.007.
  • Related Articles

    [1]Luo Yi, Wang Meng-jing, Liu Shu-fen, Yuan Shuang, Huang Hao. Astragalin improved mitochondrial function through AMPK/PGC-1α pathway and alleviated renal injury in diabetic nephropathy[J]. Journal of Clinical Nephrology, 2024, 24(11): 930-937. DOI: 10.3969/j.issn.1671-2390.2024.11.007
    [2]Li bo, Zhang Yan-fang, Zhang Xue, Zhang Han-fang, Zheng Ya-li. Relationship between serum hypoxia-inducible factor-1α and renal interstitial disease and its prognosis in IgA nephropathy[J]. Journal of Clinical Nephrology, 2024, 24(7): 567-571. DOI: 10.3969/j.issn.1671-2390.2024.07.006
    [3]A Rou-na, HE Fang-fang, SUN Xin, LUO Zhang-qing. Role of hypoxia inducible factor pathway in cardiorenal syndrome and application prospect of HIF stabilizer[J]. Journal of Clinical Nephrology, 2022, 22(2): 155-160. DOI: 10.3969/j.issn.1671-2390.2022.02.012
    [4]WU Xue-bing, AO Hua, LI Ming. Effects of Taohong Siwu Decoction on renal protection and ERK1/2/HIF-1α signaling pathway in rats with mesangial proliferative glomerulonephritis[J]. Journal of Clinical Nephrology, 2022, 22(2): 139-146. DOI: 10.3969/j.issn.1671-2390.2022.02.009
    [5]Gao Ting-ting, Hao Xiu-ying, Wu Xiao-meng, Lu Ting, Ma Ying-huan. Mechanism of inhibiting renal tubular epithelial cell transformation by silencing dendritic cell CRR7 receptor[J]. Journal of Clinical Nephrology, 2021, 21(11): 924-928. DOI: 10.3969/j.issn.1671-2390.2021.11.007
    [6]Xiao Zhen-meng, Li Zhi-lian, Dong Wei, Zhang Meng-xi, Chen Yuan-han, Li Rui-zhao, Liang Xin-ling. Changes of PGC-1α/TFAM signaling pathway and mitochondrial dysfunction of renal tubular epithelial cells during sepsis-associated acute kidney injury[J]. Journal of Clinical Nephrology, 2021, 21(6): 498-506. DOI: 10.3969/j.issn.1671-2390.m20-258
    [7]YAO Dan-dan, QIU Fang-xin, ZHANG Da-wei, LI Zuo-lin. The correlation between serum SGK1 and vascular calcification in maintenance hemodialysis patients[J]. Journal of Clinical Nephrology, 2020, 20(8): 643-647. DOI: 10.3969/j.issn.1671-2390.2020.08.006
    [8]DENG Yang-jun, HUANG Fen-fen, XIE Xiao-hang, WAN Jia-ying, LIAO Wen-juan, XIONG Fei. A study on the relationship between urinary protein-creatinine ratio and 24-hour urinary protein quantity in patients with chronic kidney disease[J]. Journal of Clinical Nephrology, 2019, 19(12): 877-882. DOI: 10.3969/j.issn.1671-2390.2019.12.003
    [9]ZHANG Xue-jing, WANG Kun, WU Yong-gui. A study on correlation of measures of urinary protein and albumin with progression of IgA nephropathy[J]. Journal of Clinical Nephrology, 2019, 19(4): 264-268,297. DOI: 10.3969/j.issn.1671-2390.2019.04.008
    [10]WENG Chang-ya, SONG Xue, ZHANG Hui, DUAN Ya-li, GUO Yu, LU Chen. Association of ELMO1 polymorphism with risk of Xinjiang Uygur diabetic kidney diseases[J]. Journal of Clinical Nephrology, 2017, 17(9): 521-525. DOI: 10.3969/j.issn.1671-2390.2017.09.002
  • Cited by

    Periodical cited type(3)

    1. 周麟,李毅,赵明. DKD患者ADPN、HIF-1α、SFRP-4和AD表达意义及相关性研究. 中国中西医结合肾病杂志. 2024(02): 136-138 .
    2. 王路路. 血清ADPN、FKN、Gremlin在糖尿病肾病患者中的表达及与患者肾功能的相关性. 承德医学院学报. 2024(04): 289-292 .
    3. 黄海,宁海虹,刘程清,屈珊. 血清HIF-1α、Cys C水平与慢性肾小球肾炎患者病情严重程度的关系及其危险因素分析. 医学理论与实践. 2023(02): 264-266 .

    Other cited types(1)

Catalog

    Article views (343) PDF downloads (279) Cited by(4)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return