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LIU Jing-qin, FENG Ran, QIAN Lin, LI Yan, YU Yang, CUI Bo-kun, WEI Wei. Correlation between mean platelet volume and glomerular filtration rate in patients with early diabetic kidney disease[J]. Journal of Clinical Nephrology, 2020, 20(9): 722-726. DOI: 10.3969/j.issn.1671-2390.2020.09.006
Citation: LIU Jing-qin, FENG Ran, QIAN Lin, LI Yan, YU Yang, CUI Bo-kun, WEI Wei. Correlation between mean platelet volume and glomerular filtration rate in patients with early diabetic kidney disease[J]. Journal of Clinical Nephrology, 2020, 20(9): 722-726. DOI: 10.3969/j.issn.1671-2390.2020.09.006
shu

Correlation between mean platelet volume and glomerular filtration rate in patients with early diabetic kidney disease

  • Department of Endocrinology, the First Hospital of Baoding, Baoding 071000, China

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  • Received Date: October 09, 2019
  • Available Online: May 11, 2023
  • Published Date: September 27, 2020
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    • Abstract
  • Objective To explore the correlation between mean platelet volume(MPV) and glomerular filtration rate(eGFR) in patients with early diabetic nephropathy,in order to lay basis for prevention and treatment of early diabetic kidney disease(DKD).Methods A total of 327 patients with type 2 diabetes who hospitalized in the First Hospital of Baoding from January 2016 to January 2019 were selected as the subjects.They were divided into 2 groups according to the urinary microalbumin/creatinine ratio(ACR):the normal albumin group(NA group,n=237)(ACR<30 mg/g),microalbuminuria group(MIA group,n=90)(ACR 31~300 mg/g),and 90 healthy adults who conducted physical examinations in our hospital in the same period were selected to be control group.The following indices were detected:platelet count(PLT),mean platelet volume(MPV),platelet distribution width(PDW),fasting pasma glucose(FPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),uric acid(UA),hyper-sensitive -C-reactive protein(hs-CRP),serum creatinine(Cr),and eGRF.SPSS21.0 statistical software was adopted to conduct t test and variance analysis.Pearson correlation analysis was used,and multi-variate Logistic regression analysis was used to analyze the influencing factors.Results The levels of MPV in the NA group and MIA group were much higher than those in control group(P<0.05),and the MPV level in the MIA group was significantly higher than that in the NA group,with statistically significant differences(P<0.05).MPV was positively correlated with HbA1c,TC,TG,SUA,SCr,ACR and hs-CRP(P<0.05).MPV was negatively correlated with eFGR and HDL-C levels(P< 0.05).Multiple stepwise regression analysis showed that HbA1c,MPV and ACR were independent risk factors for early diabetic kidney disease in patients with T2DM(P< 0.05).Conclusions MPV is negatively correlated with eGFR in diabetic patients,and may be taken as an early diagnosing biomarker of early diabetic kidney disease.
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    • References (20)
  • [1]
    Ekici B,Erkan AF,Alhan A,et al.Is mean platelet volume associated with the angiographic severity of coronary artery disease?[J].Kardiologia Polska,2013:832-838.DOI: 10.5603/kp.2013.0195.
    [2]
    Ghahremanfard F,Asghari N,Ghorbani R,et al.The relationship between mean platelet volume and severity of acute ischemic brain stroke[J].Neurosci Riyadh Saudi Arab,2013,18(2):147.DOI: 10.32331CH-13177
    [3]
    Kodiatte TA,Manikyam UK,Rao SB,et al.Mean platelet volume in Type 2 diabetes mellitus[J].J Lab Physicians,2012,4(1):5-9.DOI: 10.4103/0974-2727.98662.
    [4]
    Citirik M,Beyazyildiz E,Simsek M,et al.MPV may reflect subcinical platelet activation in diabetic patients with and without diabetic retinopathy[J].Eye,2015,29(3):376.DOI: 10.1038/eye.2014.298.
    [5]
    柯箫韵,翟海龙,黄飞.黄石社区2型糖尿病肾病患病率调查及其相关因素研究[J].中国全科医学,2013,16(12):1373-1375.DOI: 10.3969/j.issn.1007-9572.2013.04.091.
    [6]
    中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中华糖尿病杂志,2018,10(1):4-67.DOI: 10.3760/cma.j.issn.1674-5809.2018.01.003.
    [7]
    中华医学会糖尿病学分会微血管并发症学组.糖尿病肾病防治专家共识(2014年版)[J].中华糖尿病杂志,2014,6(11):792-801.DOI: 10.3760/cma.j.issn.1674-5809.2014.11.004.
    [8]
    Saran R,Li Y,Robinson B,et al.US renal data system 2014 annual data report:epidemiology of kidney disease in the United States[J].Am J Kidney Dis,2015,66(1 Suppl 1):Svii,S1-S305.DOI: 10.1053/j.ajkd.2015.05.001.
    [9]
    Zhang LX,Long JY,Jiang WS,et al.Trends in chronic kidney disease in China[J].N Engl J Med,2016,375(9):905-906.DOI: 10.1056/NEJMc1602469.
    [10]
    Cay N,Unal O,Kartal MG,et al.Increased level of red blood cell distribution width is associated with deep venous thrombosis[J].Blood Coagulation Fibrinolysis,2013,24(7):727-731.DOI: 10.1097/MBC.0b013e32836261fe.
    [11]
    Demirin H,Ozhan H,Ucgun T,et al.Normal range of mean platelet volume in healthy subjects:Insight from a large epidemiologic study[J].Thromb Res,2011,128(4):358-360.DOI: 10.1016/j.thromres.2011.05.007.
    [12]
    Han JS,Park KS,Lee MJ,et al.Mean platelet is a prognostic factor in patients with acute kidney requiring contiuous renal replacement therapy[J].J Crit Care,2014,29(6):1016-1021.DOI: 10.1016/j.jcrc.2014.07.022
    [13]
    Turgutalp K,Özhan O,Akbay E,et al.Mean platelet volume and related factors in patients at different stages of diabetic nephropathy[J].Clin Appl Thromb Hemost,2014,20(2):190-195.DOI: 10.1177/1076029612456734.
    [14]
    Bayram SM,Gürsoy G,Araz Güngör A,et al.The relationship of mean platelet volume with microalbuminuriain type 2 diabetic patients[J].Turk J Med Sci,2016,46:251-258.DOI: 10.3906/sag-1410-94.
    [15]
    Tavil Y,Sen N,Yazici H,et al.Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients[J].Platelets,2010,21(5):368-372.DOI: 10.3109/09537101003628421.
    [16]
    Dindar S,Cinemre H,Sengul E,et al.Mean platelet volume is associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus[J].West Indian Med J,2013,62(6):519-523.DOI: 10.7727/wimj.2012.284.
    [17]
    白秀平,赵宝珍.糖尿病肾病中血小板的异常[J].国外医学(内科学分册),2003,30(12):521-523.
    [18]
    Verdoia M,Schaffer A,Barbieri L,et al.Diabetes,glucose control and mean platelet volume:a single-centre cohort study[J].Diabetes Res Clin Pract,2014,104(2):288-294.DOI: 10.1016/j.diabres.2013.12.020.
    [19]
    Vernekar PV.Comparison of mean platelet volume in type 2 diabetics on insulin therapy and on oral hypoglycaemic agents[J].J Clin Diagn Res,2013,7(12):2839-2840.DOI: 10.7860/jcdr/2013/7636.3771.
    [20]
    Dolasık I,Sener SY,Celebı K,et al.The effect of metformin on mean platelet volume in dıabetıc patients[J].Platelets,2013,24(2):118-121.DOI: 10.3109/09537104.2012.674165.
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