Correlation of Vitamin D with left ventricular hypertrophy in maintenance hemodialysis patients

Objective To study the relationship between left ventricular hypertrophy(LVH)and Vitamin D 25(OH)D₃ in maintenance dialysis patients.Methods The clinical and laboratory results of 80 patients with maintenance dialysis were retrospectively analyzed.Meanwhile,Vitamin D levels were detected with radioimmunoassay.The relationships between serum Vitamin D levels and some laboratory parameters were analyzed by using Pearson correlation analysis.The risk factors of left ventricular hypertrophy were investigated through Logistic regression analysis.ROC curve was used to analyze 25(OH)D₃ and predict the optimal cutoff value of LVH.Results Serum 25(OH)D₃ levels of 80 patients with maintenance hemodialysis were(15.2±3.6)ng/mL.The 25(OH)D₃ levels of the patients in the LVH group were significantly lower than those in the non-LVH group(13.5±2.8)vs(17.8±3.2)ng/mL,P<0.05.The 25(OH)D₃ levels exhibited negative correlation with left ventricular end diastolic diameter(LVDd),left ventricular posterior wall thickness(LVPWT),interventricular septum thickness(IVST)and left ventricular mass index(LVMI),and positive correlation with left ventricular ejection fraction(LVEF)(r=-0.582,P=0.032;r=-0.562,P=0.038;r=-0.498,P=0.046;r=-0.641,P=0.024;r=0.726,P=0.018).Multivariable logistic regression analysis showed that low 25(OH)D₃,C-reaction protein(CRP),total cholesterol(TC),hypertension,anemia were independent risk factors for LVH;ROC curve analysis showed the area under the curve that baseline serum Vitamin D deficiency was used to predict an area under the curve of 0.842,with the optimal cutoff value of 14.28 ng/mL,sensitivity of 68.8% and specificity of 81.2%.Conclusions The 25(OH)D₃ levels of patients with maintenance hemodialysis decrease significantly,and vitamin D deficiency is an independent factor of LVH in MHD patients.Vitamin D deficiency may be involved in pathogenesis and progression of cardiovascular diseases in hemodialysis patients.