Clinical and pathogenic bacteria analysis of 1003 children with urinary tract infection in Wuxi

Objective To investigate the clinical features, common pathogens and their drug resistance in children with urinary tract infection in Wuxi area. Methods The clinical and urinary bacteria culture test and drug susceptibility test results of 1 003 children with urinary tract infections admitted to our nephrology department from January 2016 to December 2018 were retrospectively analyzed. The data were analyzed by SPSS 20.0 statistical software. Results Urinary tract infection in children was more common in girls less than 3 years old. 65.70% of the children with urinary tract infection were complicated with respiratory tract infections,33.60% with abnormal urinary tract structure. 9.37% with sepsis, 8.47% with diarrhea, etc. In addition, 191 strains (19.04%) of pathogens were detected in 1 003 patients. Among the cases, 111 ones were related to Gram-negative bacteria,(58.12%),and Escherichia coli ranked first with 75 cases(39.27%); 78 ones (40.84%) to Gram-positive bacteria, of which Enterococcus faecium was dominantwith 43 cases(22.51%).There was no significant difference in pathogenic bacteria between patients with normal urinary tract and abnormal urinary tract (χ²=2.616,P>0.05). The resistance rates of Escherichia coli to ampicillin, cefazolin and ceftriaxone were all over 70%, while the resistance rates to imipenem, furantoin, piperacillin/tazobactam, ceftitam, cefepime and ceftazidime were low. Enterococcus faecium had a resistance rate of more than 60% to ampicillin, clindamycin and erythromycin, but less resistant to vancomycin, linezolid and furantoin. Conclusions Children with fever and respiratory tract infection diagnosed first, especially infants, should pay attention to the identification of urinary tract infection. Escherichia coli is still a common pathogen in children with urinary tract in-fections. The detection rate of Enterococcus has increased in recent years, and more attention should be paid to bacterial culture of mid-stream urine.