Significance of genetic sequencing for chronic kidney diseases

Chronic kidney diseases (CKDs) have always been a major health problem that puzzles the whole world. CKD patients are faced with the risk of high morbidity, high mortality and high hospitalization rate. Therefore, the early screening and intervention of CKDs are of great significance to improve the prognosis of the patients. However, many patients with chronic kidney diseases have lost the opportunity of early treatment because their clinical symptoms are not obvious and can not be diagnosed clearly. With the development of human genome project and gene sequencing technology, more and more genes have been confirmed to be closely related to many chronic kidney diseases, such as polycystic kidney disease, Fabry's disease and autosomal dominant tubular interstitial disease (ADTKD). These genes affect the occurrence and development of CKD through interaction with environment or Mendelian inheritance. This article aims to introduce the significance of gene sequencing for CKDs in the aspects of their diagnosis, treatment, reproductive guidance and pre-transplant evaluation.