Clinical study on the correlation of early renal damage in patients with hypertension with different salt intake

Objective To study the correlation of early renal injury in hypertension patients with different salt intake. Methods Selection in our hospital between January 2015 and December 2015, in line with the selected conditions of 2 964 cases of primary hypertension, male 1 382 cases, 1 582 cases of women, according to quartile is divided into low salt intake, the intake group, high intake group, high intake, collecting relevant data including age, sex, course of past history, smoking, drinking, etc.; Blood samples:blood potassium, blood sodium, blood creatinine, blood urea nitrogen, blood glucose, serum uric acid, serum cystatin C, triglyceride, total cholesterol, low density lipoprotein, HDL. Urine samples:24 hours of urine sodium and urine microalbumin were studied and analyzed. Results the four sets of normal data are no different. (P>0.05); In male patients, the salt intake of 11.4(7.4,15.4)g/d was higher than that of female salt intake by 9.2 (6.5,12.5)g/d, with statistical difference (P<0.05). Trace albumin respectively different salt intake group of 24 hours (2.31±0.12), (2.62±0.14), (2.75±0.13), (3.09±0.15), high intake of trace albumin group and a high intake of 24 hours in the group were significantly higher than that of low intake and intake group (P<0.05), high intake of trace albumin is higher than the high intake of 24 hours group (P<0.05). In 2 964 patients were included in the 525 patients were detected renal damage, the proportion is 17.71%, renal lesion detection rate is respectively 88 different salt intake group (11.45%), 91 (11.37%), 155 (20.16%), 191 (30.46%), high consumption groups and a high intake of renal damage in the group were significantly higher than that of low intake and intake group (P<0.05); The detection rate of renal damage was higher in the high intake group than in the middle and high intake group (P<0.05). The correlation between salt intake in patients with hypertension and microalbumin in 24 hours (r=0.153, P<0.01). Multivariate linear regression analysis showed that, in the observation group, patients with 24-hour urinary microalbumin and independent variables were observed to have salt content (OR=16.542, 95%CI 2.498-25.365). P=0.001), systolic pressure (OR=10.582,95%CI 1.046-12.695 P=0.049), blood glucose (OR=2.594, 95%CI 1.125-15.361; P=0.019), blood uric acid (OR=10.265, 95% CI 3.458 to 24.236, P=0.02). Conclusions Long-term high salt intake leads to independent risk factors for early renal damage, and the more salt is consumed daily, the greater the damage degree of renal kidney. Systolic blood pressure, blood uric acid and blood glucose were closely related to the occurrence of microalbumin in 24 hours.