Research progresson correlation of PLA2R1 and HLA gene polymorphisms with susceptibility toidiopathic membranous nephropathy

Membranous nephropathy (MN) is one of the most common pathological types of nephrotic syndromes in adults. The incidence peak appearsat the age of 40 to 50 in, more men than women. The pathological features are diffused deposition of immune complexes under the glomerular visceral epithelial cells, thickening of the basement membrane with spike formation. The most common pathological type of glomerular diseases is IgAN, followed by MN, and MN is growing at a rate of 13% per year, which has a tendency to exceed IgAN. Studies have shown that about 1/3 of idiopathic membranous nephropathy(IMN) manifest as spontaneous remission, about one-third of which is characterized by persistent proteinuria, and about one-third of it enters end-stage renal disease (ESRD) within 10 years. In recent years, IMN has been studied from the perspective of genetics, and it is believed that progression of IMN is related to the polymorphic sites of certain genes. In this review, we described research progress on the role of PLA2R1 and HLA gene polymorphisms in susceptibility to idiopathic membranous nephropathy.