Investigation on influencing factors and prognosis of complicated infection in patients with maintenance hemodialysis

Objective To know about influencing factors of complicated infection in patients with maintenance hemodialysis (MHD),and to understand characteristics,prognosis and influencing factors of complicated infection in patients with MHD.Methods Clinical data of MHD patients hospitalized in Guiyang First People's Hospital from January 2012 to December 2017 were collected,and divided into the infection group and the non-infection group based on presence of complicated infection.General information and laboratory test results of these patients were collected,so as to analyze infectious factors in them and summarize types of pathogens and infections in them.Based on prognosis of these patients with MHD,they were divided into the good prognosis group and the poor prognosis group,so as to analyze influencing factors of their prognosis.Results Through comparison of the data between the infection group and the non-infection group,it was found that the risk for complicated infection increased significantly for those patients with a primary disease of diabetic nephropathy.Kt/V<1.2,and use of a ferric preparation,hemoglobin<110 g/L and albumin<40 g/L in recent 3 months (P<0.05).In the MHD patients hospitalized due to infection,the most common infectious bacteria included Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa and,staphylococcus aureus,and infection of the respiratory system is the most common.Multi-factor regression analysis revealed that the factors influencing prognosis of complicated infection in the patients with MHD included age>65,bed time>10 days,requirement for blood transfusion,multiple drug-resistant bacterial infection,and malnutrition,with statistically significant difference (P<0.05).Conclusions Primary diabetic nephropathy,Kt/V<1.2,and use of a ferric preparation,hemoglobin<110 g/L and albumin<40 g/L in recent 3 months are the risk factors of complicated infection in MHD patients;infection of the respiratory tract is the most common;and,age>65,bed time>10 days,requirement for blood transfusion,multiple drug-resistant bacterial infection and malnutrition are the hazardous factors of prognosis of complicated infection in patients with MHD.