Diagnostic value of thrombus elasto graph in hypercoagulability of membranous nephropathy

Objective Thrombus elasto graph (TEG) was used to investigate the related factors of hypercoagulability in patients with membranous nephropathy (MN). Methods From September 2017 to July 2018, 61 patients with MN and 36 patients with minimal change (MCD) diagnosed by renal biopsy in the First Affiliated Hospital of Bengbu Medical College were selected as the study subjects, and 20 healthy subjects as the control group. MN and MCD patients were divided into two subgroups according to serum albumin (Salb) level (<20 g/L or 20-30 g/L). Main outcome measures included response time (R), angle alpha, maximum amplitude (MA) and coagulation index (CI). TEG parameters and Salb were analyzed by the variance analysis. Results Linear regression analysis showed that TEG parameters in MN patients were correlated with Salb (P<0.01). The R value in normal control group was significantly higher than that in MN subgroup, but there was no significant difference between normal control group and MCD subgroup. The values of alpha, MA and CI in NS patients (MCD, MN) were significantly higher than those in healthy controls (P<0.05). Conclusions Patients with MN tend to have hypercoagulable state more than normal and MCD patients. Hypercoagulability in MN patients involves the acceleration of thrombogenesis, including the endogenous pathway of activation, fibrinogen, platelet function and fibrin-platelet interaction. Hypercoagulability in MCD patients may be due to inactivation of coagulation factors. Especially for patients with severe hypoalbuminemia, MN should be strengthened to prevent hypercoagulability.