Analysis of risk factors for hyperlipidemia in 1233 maintenance hemodialysis patients

Objective To investigate the risk factors of hyperlipidemia in patients with maintenance hemodialysis (MHD).Methods A cross-sectional study was conducted in 10 blood purification centers in Guangdong from January 2018 to April 2018 for more than 3 months of MHD. Data of general condition, dialysis related data and complications during dialysis were analyzed.Results 1 233 MHD patients were enrolled, including 719 males (58.8%), with an average age of 56 years, and height of 163 cm. Hemodialysis filtration (HDF) was performed on 480 cases (38.9%), and hemoperfusion (HP) on 101 cases (8.2%). For basic kidney diseases, there were 630 cases of primary glomerular disease (51.3%), 281 cases of diabetic nephropathy (22.9%), 71 cases of hypertensive renal injury (5.8%), 17 cases of chronic renal tubular interstitial disease (1.4%), 88 cases of obstructive nephropathy (7.2%), 7 cases of lupus nephritis (0.6%), 51 cases of polycystic kidney cases (4.2%), 15 cases of gouty nephropathy (1.2%), 15 cases of hepatitis B related nephropathy (1.2%), and 60 cases of other kidney diseases (4.9%). Multiple factor Logistic regression analysis revealed that sex and blood calcium were closely related to hyperlipidemia in patients with MHD, and HP was an importantly protective factor for hyperlipidemia in MHD patients (P<0.05).Conclusions Hyperlipidemia is one of the most common complications in MHD patients. The sex and blood calcium level are the independent risk factors for hyperlipidemia in MHD patients. The HP may be effective in preventing hyperlipidemia in MHD patients.