Effect of continuous nursing on neutrophil gelatinase-associated lipocalin in patients with lupus nephritis

Objective To investigate the influence of continuous nursing on serum creatinine (SCr) and blood urea nitrogen (BUN), serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) level in patients with lupus nephritis (LN). Methods Sixty cases of LN were randomly divided into 2 groups:control group (routine nursing) and observation group (continuous nursing). Levels of SCr and BUN in serum, serum and urinary NGAL were measured by ELISA at discharge and 6 months after hospital discharge. Results At 6th month after discharge, serum SCr and BUN, serum and urinary NGAL had no significant elevation in observation group as compared with those at discharge, and significantly reduced in observation group as compared with those in control group (P<0.05). The satisfaction in observation group was significantly higher than that in control group (93.3% vs. 60.0%, P<0.05). Urinary NGAL was closely correlated with LN. Conclusions Continuous nursing intervention can control SCr, BUN and NGAL levels in patients with LN after the symptoms are stable and discharged. Continuous nursing can slow the progression of the disease, and improve the degree of patient's satisfaction, which is worth further promotion in the clinical practice.