Expression of sFlt-1 and LAMP-2 in serum of patients with chronic glomerulonephritis and their correlation analysis

Objective To investigate the expression level and correlation of sFlt-1 and LAMP-2 in the serum of patients with ANCA-associated nephritis. Methods Ninety cases of ANCA-associated nephritis were selected as the study group from October 2016 to October 2017, and were classified into low-proteinuria subgroup and high-proteinuria subgroup according to 24-h proteinuria level. A total of 90 patients with chronic glomerulonephritis were selected as the control group and 50 healthy subjects as the healthy group. The levels of sFlt-1 and LAMP-2 in serum and urine samples from different groups were compared, and the correlation between sFlt-1 and LAMP-2 levels with ANCA-associated nephritis and 24-h urine protein was analyzed. Results The levels of sFlt-1 and LAMP-2 in the serum and urine samples of the study group were significantly higher than those in the control group and the healthy group (P<0.05). Logistic multiple regression analysis of sFlt-1 and LAMP-2 in urine and serum showed that serum LAMP-2 and urine sample LAMP-2 were risk factors for ANCA-associated nephritis (P<0.05). In patients with ANCA-associated nephritis (study group), the levels of sFlt-1 and LAMP-2 in serum and urine samples of patients with high proteinuria were significantly higher than those of low proteinuria (P<0.05), and healthy group (P<0.05). There was a significant positive correlation between sFlt-1 and LAMP-2 in serum and urine samples with 24-h urine protein in patients with ANCA-associated nephritis (P<0.05). Conclusions The levels of sFlt-1 and LAMP-2 in serum and urine of patients with chronic glomerulonephritis were significantly increased. The level of LAMP-2 in patients with ANCA-associated nephritis was significantly higher than that in patients with chronic glomerulonephritis, and LAMP-2 in serum and urine is a high risk factor for ANCA-associated nephritis.