Curative effectiveness of hemoperfusion combined with cinacalcet for bone pain in patients with uremia

Objective To study the curative effectiveness of hemoperfusion combined with cinacalcet for bone pain in uremia patients. Methods Totally patients with maintenance hemodialysis who were suffered with severe bone pain were randomly divided into group A (HD group), group B (HD+HP group) and group C (HD+HP+cinacalcet group). Plasma Ca²⁺, plasma P³⁺ and parathyroid hormone (PTH) were measured pre-dialysis, 2 weeks and 6 weeks after treatment. Bone pain was scored. Results Compared with pre-dialysis, the levels of plasma P³⁺, PTH and the scores of bone pain were significantly lower at 2nd and 6th week after treatment in group C (P<0.05). There were statistically significant difference in plasma P³⁺, PTH and scores of bone pain among 3 groups at 6th week (P<0.05). Conclusions HD+HP+cinacalcet is superior to HD+HP in efficiently clear plasma P³⁺ and PTH, and relief bone pain, but HD can poorly clear plasma P³⁺ and PTH, and relief bone pain.