A study on the correlation between serum 25(OH)D₃ and CKD

Objective To explore the relationship between serum 25(OH)D₃ and CKD. Methods Selected January 2014 to January 2016 in The fifth people's hospital of Longgang district Shenzhen diagnosed 120 cases of patients with CKD, according to glomerular filtration rate (EGFR) were divided into 5 group. We selected 30 healthy people as control group. We measured serum 25(OH)D₃ level and related laboratory parameters, and analyzed the correlation. Results The levels of SCr, eGFR, albumin, PTH, Hb and 25(OH)D₃ in the control group and patients with CKD were statistically significant (P<0.05). With the increase of stage, the levels of SCr and PTH increased gradually, and the levels of eGFR, Hb and 25(OH)D₃ decreased gradually. There was no significant difference in serum calcium and blood phosphorus between the groups (P>0.05). The proportion of patients with CKD stage 4 and stage 5 with 25(OH)D₃ levels was significantly higher than that of the control group, CKD stage 1, stage 2, and stage 3 (P<0.05). The proportion of patients with CKD stage 5 with 25(OH)D₃ levels was significantly higher than that of CKD stage 4 patients (P<0.05). There was a significant negative correlation between 25(OH)D₃ with SCr, albumin,PTH in CKD patients (P<0.05). There was a significant positive correlation between 25(OH)D₃ with eGFR and Hb (P<0.05). Conclusions The level of 25(OH)D₃ in patients with CKD is lower than in healthy people and is closely related to the degree of renal impairment in patients with CKD.