Investigation on mineral and bone abnormalities in 123 maintenance hemodialysis patients

Objective To investigate and analyze the controlling situation of mineral and bone disorder (MBD) in maintenance hemodialysis patients, analyze their related factors, and discuss control methods.Methods We investigated MBD in 123 maintenance hemodialysis patients and compared these data with the guidelines. We also analyzed age, gender, years for dialysis, hemoglobin (Hb), renal function, alkaline phosphatase (ALP), blood pressure and diabetic mellitus in these patients.Results In the 123 cases, Serum Ca in 84 (68.29%) cases, phosphate in 35 (28.46%) cases, and iPTH in 69 (56.10%) cases met the requirements of the guidelines. However, normal values of the above 3 parameters recommended by KDIGO were only found in 13 (10.57%) cases. MBD was correlated with age, renal function, β2-MG, blood pressure, ferritin, ALP, Kt/V. However, gender, years for dialysis, BMI and diabetic mellitus were not correlated with MBD. In addition, higher level of ALP was correlated with higher iPTH level. But hemodialysis patients with diabetic mellitus in lower iPTH level group were more than other groups.Conclusions CKD-MBD has a high incidence in MHD. There was still a long distance between the biochemical indicator of our hemodialysis center and the guideline. The age, years for dialysis, blood pressure, Hb, phosphate, iPTH, the use of calcium phosphate binder, and the use of active vitamin D were the main factors which influence the MBD in MHDs. A better prevention and control method still needs to implement in our hemodialysis center.