Clinical effect of Jinshuibao capsule in the treatment of diabetic nephropathy

Objective To investigate the clinical effect of Jinshuibao capsule in the treatment of diabetic nephropathy (DN).Methods A total of 200 patients with DN admitted to Ezhou Hospital of Traditional Chinese Medicine from March 2015 to March 2017 were treated with Jinshuibao capsule for 4 months, and 50 healthy subjects were selected as the control group. According to urinary albumin excretion rate, 200 patients with DN were divided into early, middle and late stages, and each stage of the patients were equally divided into groups A and B. In group A, patients were given routine DN treatment. In group B, patients were treated with Jinshuibao capsules on the basis of routine treatment. The clinical efficacy, fasting blood glucose, 2-h postprandial blood glucose, glycosylated hemoglobin, urea nitrogen, serum creatinine and 24-h proteinuria were measured in each group, and the statistical analysis was performed.Results The effective rate of Jinshuibao capsule treatment in the early, middle and late groups was 77.27%, 81.82% and 76.47%, respectively, which had a remarkably improved clinical effect (P<0.05). As compared with the control group, Jinshuibao capsule could effectively reduce the urinary protein excretion rate, blood urea nitrogen, serum creatinine and 24-h proteinuria of patients with diabetic nephropathy. Meanwhile, it could also increase the fasting plasma glucose, 2-h postprandial blood glucose and HbA1c levels with a significant difference (P<0.05).Conclusions Jinshuibao capsule has a satisfactory clinical effect on diabetic nephropathy, which can effectively relieve renal vascular lesions and injuries caused by diabetic nephropathy.