Effect of high-flux dialysis on the levels of AGEs and microinflammation in patients with diabetic kidney disease

Objective To investigate the effect of high-flux dialysis on the levels of AGEs, CRP, IL-6 and TNF-α in patients with diabetic kidney disease (DKD).Methods Sixty patients with early DKD were enrolled in this study during October 2015 to November 2017. Thirty patients in experimental group received high-flux dialysis with ultrafiltration coefficient of 40 ml·h^-1·mmHg^-1, and 30 patients in control group received conventional hemodialysis with ultrafiltration coefficient of 16 ml·h^-1·mmHg^-1, 3 times per week, 4 h each, for 2 months. The levels of AGEs, CRP, IL-6 and TNF-α pre-and post-dialysis were measured.Results The levels of AGEs, CRP, IL-6 and TNF-α in the experimental group were higher than in the control group and the difference was statistically significant (P<0.05). The levels of AGEs, CRP, TNF-α and IL-6 in the experimental group were significantly lower than those before dialysis (P<0.05) after single and continuous high-flux dialysis. There was no significant change in the AGEs level after a single conventional hemodialysis, while the levels of CRP, TNF-α and IL-6 in the control group were significantly increased (P<0.05). After continuous conventional hemodialysis, the levels of AGEs increased, while the levels of TNF-α increased further (P<0.05). Conclusions Patients with DKD were in obvious inflammatory state, and high-throughput dialysis can remove AGEs, CRP, IL-6, TNF-α effectively. Compared with conventional hemodialysis, high-flux dialysis benefits patients with DKD.