Randomized controlled single-center trial of ferrous succinate and polysaccharide iron complex in the treatment of anemia induced by non-dialysis chronic kidney disease

Objective To compare the curative effect of ferrous succinate and polysaccharide iron complex on the anemia of non-dialysis chronic kidney disease (ND-CKD) patients.Methods Twenty ND-CKD patients in our hospital were selected and divided into two groups according to the randomization method. Blood routine, iron metabolism index, liver function, renal function, and hs-CRP were examined at the baseline and at 1st, 2nd, 3rd, 4th, 5th and 6th month after treatment. The qualified rate and increase of hemoglobin from baseline were observed and compared.Results As compared with the polysaccharide iron complex group, hemoglobin (Hb) increased significantly after treatment with ferrous succinate complex for 3 and 6 months. The difference was not significant, although both groups showed an increase in both ferritin and transferrin saturation. The increase in red blood cells and serum iron was greater after treatment for 6 months. At 4th, 5th and 6th month after treatment, the qualified rate in ferrous succinate complex group was significantly higher than in the polysaccharide iron complex group. There was significant difference in counts of red blood cells (RBC), Hb and red cell distribution width (RDW) between two groups after treatment for 6 months. There was no significant difference in liver function, hs-CRP and eGFR between two groups during the treatment duration of 6 months.Conclusions Iron supplement is a necessary means to correct anemia in patients with ND-CKD. Oral iron is a commonly used method of iron supplementation in clinic. After the treatment of ferrous succinate, Hb increased significantly and was more effective. Ferrous succinate can also improve RDW at the same time.