Expression and clinical significance of collectin 11 in sepsis-induced acute kidney injury

Objective To investigate the expression and clinical significance of collectin 11 (CL-11) in sepsis-induced acute kidney injury (AKI) patients.Methods In this study, 65 AKI patients and 30 healthy individuals were included. Serum CL-11 levels in AKI patients at days 1, 3 and 7, and urine kidney injury molecule-1 (KIM-1) levels in both AKI patients and controls were examined. The AKI stage, serum creatinine (SCr), duration of renal replacement therapy (RRT) and prognosis were analyzed.Results Serum CL-11 level in sepsis-induced AKI patients was significantly higher than in the healthy controls (P<0.01). Serum CL-11 levels were correlated to the progression of AKI with a peak at day 3. Furthermore, the baseline serum CL-11 level was higher in patients who subsequently died. Baseline serum CL-11 levels were positively correlated with the urine KIM-1 levels, AKI stage and RRT duration.Conclusions Elevated serum CL-11 was associated with worse AKI clinical outcomes. This finding suggests that CL-11 may be useful as a biomarker of AKI prognosis.