The clinical efficacy and action mechanism of Bailing capsule in the treatment of microinflammatory and the condition of malnutrition in maintenance hemodialysis patients

HUANG Qiao; OUYANG Xu-ming; CHEN Wen-li

doi:10.3969/j.issn.1671-2390.2018.05.010

Journal of Clinical Nephrology > 2018 > 18(5): 299-302. > DOI: 10.3969/j.issn.1671-2390.2018.05.010

HUANG Qiao, OUYANG Xu-ming, CHEN Wen-li. The clinical efficacy and action mechanism of Bailing capsule in the treatment of microinflammatory and the condition of malnutrition in maintenance hemodialysis patients[J]. Journal of Clinical Nephrology, 2018, 18(5): 299-302. DOI: 10.3969/j.issn.1671-2390.2018.05.010

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The clinical efficacy and action mechanism of Bailing capsule in the treatment of microinflammatory and the condition of malnutrition in maintenance hemodialysis patients

Department of Nephrology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China

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Received Date: July 19, 2017
Rev Recd Date: January 29, 2018
Available Online: May 11, 2023
Published Date: May 27, 2018

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Abstract

Objective To investigate the clinical efficacy and action mechanism of Bailing capsule in the treatment of microinflammatory and the condition of malnutrition in maintenance hemodialysis (MHD) patients. Methods A total of 100 MHD patients who were treated in the Hemodialysis Center of Wuhan Central Hospital from March 2016 to September 2016 were enrolled in the study and randomly divided into two groups. Among them, there were 58 males and 42 females, aged 29 to 70 years, with an average of (45.6±12.4) years. All patients were clinically judged to have dry weight and given long-term pathway establishment. All patients did not take bailing capsules, glucocorticoids and compound a-ketoacid tablets within 3 months before the start of the study. There was no statistically significant difference between the two groups in terms of sex, age, pathogenesis, hemodialysis mode and anemia. In the control group, MHD was given, blood pressure was controlled, anemia and the disorders of calcium-phosphate metabolism corrected, and symptomatic supportive treatment done. In the treatment group, patients were given Bailing capsule (1.0 g, thrice every day) additionally. Changes in hs-CRP, TNF-α, IL-6, Alb, PA, TC and nutritional status were observed before and after treatment in the two groups. Results The hs-CRP, TNF-α and IL-6 levels were decreased significantly in the two groups after the treatment (P<0.05), more significantly in the treatment group than in the control group (P<0.05). MQSGA was markedly improved in the treatment group as compared with the control group (P<0.05). There was no statistically significant difference between the two groups in terms of Alb and TC after treatment. Conclusions Bailing capsule can improve microinflammatory and the condition of malnutrition in MHD patients, probably by reducing anti-inflammatory factors and promoting the protein synthesis and use of amino acids.
- Maintenance hemodialysis,
- Bailing capsule,
- Microinflammatory status,
- Malnutrition

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[1]	Tinroongroj N, Jittikanont S, Lumlertgul D. Relationship between malnutrition-inflammation syndrome and ultrafiltration volume in continuous ambulatory peritoneal dialysis patients[J]. J Med Assoc Thai, 2011, 94 Suppl 4:S94-100.
[2]	Chan M, Kelly J, Batterham M, et al. Malnutrition (subjective global assessment) scores and senlm albumin levels, but not body mass index values, at initiation of dialysis are independent predictors of mortality:a 10-year clinical cohort study[J]. J Ren Nutr, 2012, 22(6):547-557.
[3]	陶静. 维持性血液透析患者与微炎症反应[J]. 肾脏病与透析肾移植杂志, 2011, 20(2):176-180.
[4]	汪嘉莉, 张林, 王松, 等. 复方α-酮酸联合醋酸钙对维持性血液透析患者钙磷代谢的影响[J]. 医学综述, 2015, 21(7):1344-1344.
[5]	周娟, 肖剑, 傅中伟, 等. 复方α-酮酸片对维持性血液透析患者微炎症状态的影响[J]. 海南医学院学报, 2014, 20(5):636-639.
[6]	Kawaguchi T, Tong L, Robinson BM, et al. C-Reactive Protein and Mortality in Hemodialysis Patients:The Dialysis Outcomes and Practice Patterns Study (DOPPS)[J]. Nephron Clin Pract, 2011, 117(2):c167-178.
[7]	Memoli B, Salerno S, Procino A, et al. A translational approach to micro-inflammation in end-stage renal disease:molecular effects of lowlevels of interleukin-6[J]. Clin Sci(Lond), 2010, 119(4):163-174.
[8]	黄龙, 廖婷婷, 龚俊, 等. 百令胶囊对糖尿病肾病慢性肾衰竭微炎症状态的影响[J]. 中国当代医药, 2014, 21(15):72-74.
[9]	Carrero JJ, Stenvinkel P, Cuppari L, et al. Etiology of the protein-energy wasting syndrome inc hronic kidney disease:a consensus statement from the International Society of Renal Nutritionand Metabolism[J]. J Ren Nutr, 2013, 23(2):77-90.
[10]	Chen J, Peng H, Yuan Z, et al. Combination with anthropometric meas-urements and MQSGA to assess nutritional status in Chinese hemodialysis population[J]. Int J Med Sci, 2013, 10(8):974-980.
[11]	Campbell KL, Bauer JD, Ikehiro A, et al. Role of nutrition impact symptoms in predicting nutritional status and clinical outcome in hemodialysis patients:a potential screening tool[J]. J Ren Nutr, 2013, 23(4):302-307.
[12]	Szklarek-Kubicka M, Fijałkowska-Morawska J, Zaremba-Drobnik D, et al. Effect of intradialytic intravenous administration of omega-3 fatty acids on nutritional status and inflammatory response in hemodialysis patients:a pilot study[J]. J Ren Nutr, 2009, 19(6):487-493.
[13]	Bednarek-Skublewska A, Zaluska W, Ksiazek A. The relationship between serum level of N-terminal pro-B-type natriuretic peptide and nutritional status, andinflammation in chronic hemodialysis patients[J]. Clin Nephrol, 2010, 73(1):14-20.
[14]	周蓉, 张芸, 蒋更如. 慢性肾脏病非透析患者营养状况的评价及分析[J]. 中国临床保健杂志, 2010, 13(4):360-363.
[15]	黎磊石. 中国肾脏病学[M]. 北京:人民军医出版社, 2008:1864.

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