Differences in serum anti-PLA2R antibody determination in Uygur patients with idiopathic membranous nephropathy in Xinjiang

Objective To detect the sensitivity and specificity of anti-PLA2R antibodies in Uygur patient with idiopathic membranous nephropathy (IMN),understand whether the serum anti-PLA2R antibody can be regarded as the biomarker in Uygur patients with IMN,then study whether there are differences in the expression of anti-PLA2R antibody between Uygurs and other nationalities. Methods The clinic data of 29 IMN patients (test group) and 29 non-IMN patients (control group) in Uygurfrom November 2016 to May 2017 were collected. IMN was diagnosed by renal puncture biopsy.In the control group,there was IgA nephropathy, minimal lesion,focal periodic glomerular sclerosis and mesangial proliferative glomerulonephritis. The fasting blood in the morning was taken out on the second day after admission. The serum anti-PLA2R antibody was detected.Clinical data were estimated by ROC curve. Results The positive rate of anti-PLA2R antibody in the test group was 58.62% (n=17/29), and that in the control group was 0. The sensitivity and specificity of serum anti-PLA2R antibody in Uygur patients with IMN were 58.62% and 100%, 95% confidence was68.9-93.9,the positive predictive value was 100%,negative predictive value was 70.73%, and the coincidence was 79.31%. Conclusions The serum anti-PLA2R antibody can be regarded as the biomarker in Uygur patients with IMN.The sensitivity and specificity of serum anti-PLA2R antibody in Uygur patients with IMN may differ from those in other nationalities.