Effect of continuous renal replacement therapy on micro-inflammatory state and renal function in patients with severe acute renal failure

Objective To investigate the effect of continuous renal replacement therapy on micro inflammatory state and renal function in patients with severe acute renal failure.Methods Eighty-four cases of severe acute renal failure were treated in our hospital from November 2014 to November 2016, and randomly divided into two groups:the observation group receiving continuous renal replacement therapy, and the control group given intermittent hemodialysis treatment. The curative effectiveness of the two groups was compared after treatment. The levels of inflammatory factors such as IL-6, IL-8, hs-CRP, TNF-α and SCr, CCr, BUN, CHE and other renal function indexes were observed and compared. APACHE Ⅱ score and complications were observed.Results After treatment, the total effective rate in the observation group was significantly higher than that in the control group (92.86% vs. 76.19%, P<0.05). After treatment, the levels of IL-6, IL-8, hs-CRP and TNF-α in the two groups were significantly lower than those before the treatment, and those in the observation group were significantly lower than in the control group (P<0.05). The SCr and BUN levels after treatment in the two groups were significantly lower, and Ccr and CHE levels were significantly higher than those before treatment, more significantly in the observation group (P<0.05). There were no significant differences in APACHE Ⅱ scores between the observation group and the control group before treatment (P>0.05). After treatment, APACHE Ⅱ scores in the observation group were lower than those in the control group (14.83±3.84 vs. 22.73±6.97, P<0.05). The common adverse reactions were hypotension and arrhythmia. The incidence of hypotension and arrhythmia in the observation group was significantly lower than that in the control group (4.76% vs. 14.29%, and 2.38% vs. 11.90%, P<0.05).Conclusions Continuous renal replacement therapy in patients with severe acute renal failure can significantly improve the state of micro inflammation and renal function, and control complications, and the curative effectiveness is remarkable.