The association of diabetic mellitus and thromboembolic disease in the hemodialysis patients in the Pearl River Delta Region-A multicenter cross section study

Objective To investigate the risk factors of thromboembolic disease and the relationship with diabetic mellitus in the hemodialysis patients(HD) in the Pearl River Delta Region. Methods 1 085 HD patients were enrolled in the study from July 1, 2016 to September 30, 2016 and assigned into the thrombus group (n=115) and non-thrombus group (n=970) in terms of the presence or absence of stroke or myocardial infarction or thrombus in arteriovenous fistula. The demographic data and blood pressure, ultrafiltration volume, Kt/V, laboratory data were collected and the risk factors of thromboembolic disease and the role of diabetes were analyzed by multiple Logistic regression. Results The patients in thrombus disease group were older(60.1±13.9) years vs. (51.8±14.0) years, P<0.01 with lower diastolic blood pressure before dialysis(79.59±10.90) mmHg vs. (82.79±11.47) mmHg, P=0.005, more blood platelets(201.77±75.35)×10⁹/L vs. (184.55±64.02)×10⁹/L, P=0.008), lower serum creatine(912.99±283.82) μmol/L vs. (1 053.65±308.01) μmol/L, P<0.01) and higher mobility of diabetes (41.7% vs.16.0%, P<0.01). The patients with diabetic mellitus were older(60.11±10.99) years vs.(50.95±14.37) years, P<0.01) and higher morbidity of stroke (14.3% vs. 2.5%, P<0.01), myocardial infarction (6.4% vs. 1.2%, P<0.01) and thrombus in arteriovenous fistula (23.6% vs.7.6%, P=0.028). The increase of age (P=0.004, OR=1.034) and blood platelets (P=0.015, OR=1.004) and the incidence of diabetes (P=0.001, OR=2.648) were the risk factors of thrombus disease by multiple regression. Conclusions The increase of age and blood platelets and the incidence of diabeteswere the risk factors of thromboembolic disease in the HD patients in the Pearl River Delta Region.