Effect of transcolonic therapy on gastrointestinal motility in patients with CKD

Objective To investigate the influence of transcolonic therapy on gastrointestinal motility in patients with CKD.Methods Forty-five health check-up individuals were selected (control group). Ninety-two patients with CKD of stage 3b to 4 (treatment group) were randomly divided into two groups:group A given conventional therapy and transcolonic therapy once a day; group B given conventional therapy only. Gastrointestinal scores (GIS), which were evaluated by a gastrointestinal self-rating scale, as well as oral-colon transit time (OCTT) measured by hydrogen breath tests were compared between control group and treatment group. The indexes above were compared before and after treatmentg between group A and group B.Results Compared to control group, the GIS were significantly increased in treatment group. Accordingly OCTT measured by HBT was obviously longer in treatment group. After treatment, GIS and the level of SCr, BUN,UA, K in group A were significantly lower than in group B. OCTT in group A was distinctly shorter in group B. Nevertheless the levels of Na and Cl had no significant difference in the two groups.Conclusions The patients with CKD show obviously gastric dysmotility. Transcolonic therapy is an efficient method to improve GIS and bradygastria in patients with CKD.