Clinical observation on the therapeutic effect of hemoperfusion combined with routine treatment for severe organophosphorus pesticide poisoning

Objective To investigate the therapeutic effectiveness of hemoperfusion in the treatment of patients with severe organophosphorus pesticide poisoning and its effect on the recovery of ChE activity and inflammatory factors. Methods Sixty-four cases of severe organophosphorus pesticide poisoning were selected from our hospital from June 2013 to January 2016, and were randomly divided into observation group (32 cases) and control group (32 cases). The two groups were treated with routine treatment. The control group was given atropine and pyraloxime methylchride treatment, and the observation group was treated with the combination of hemoperfusion on the basis of the control group. The changes in serum ChE levels in two groups were compared before and after treatment. ChE activity recovery time, the duration of symptoms of central nervous system, N like, M like duration of symptoms, duration of symptoms, hospital stay and mortality, changes in serum CRP and IL-6 levels before and after treatment were measured. Results Serum ChE levels were increased after treatment in the two groups (P<0.05). Serum ChE levels after treatment in the observation group were higher than in the control group (P<0.05). ChE activity in the observation group recovered faster than in the control group (P<0.05). The central nervous symptom duration, the duration of N like symptoms and M symptoms, and hospital stay were significantly shorter in the observation group than in the control group (P<0.05). After treatment, serum CRP and IL-6 levels were significantly reduced in both two groups (P<0.05). Serum CRP and IL-6 levels after treatment were lower in the observation group than in the control group (P<0.05). Conclusions The effect of hemoperfusion in the treatment of organophosphorus pesticide poisoning patients is significant, which can significantly improve the recovery of ChE activity, and can reduce the levels of serum CRP and IL-6.