Analysis of related factors in maintenance hemodialysis patients with renal anemia

Objective To observe the renal anemia in maintenance hemodialysis (MHD) patients, analyze the related factors, and understand the relationship between hepcidin expression level and renal anemia in MHD patients.Methods This cross-sectional study was carried out in 128 MHD patients, including72 males and 56 females, with a mean age of (53.50±13.26) years and a mean dialysis vintage of (32.13±17.04) months from August 1 to 28, 2016. The clinical data of the patients were collected, and parameters such as routine blood test, C-reactive protein (CRP), Hepcidin, serum iron, ferritin, unsaturated iron-binding capacity (UIBC), electrolyte, folic acid, vitamin B12, parathyroid gland hormone (iPTH) and electrolyte were measured before the mid-week hemodialysis. Blood creatinine and urea nitrogen were detected before and after dialysis, and single chamber urea clearance index (sp Kt/V) was calculated.Results The mean hemoglobin in 128 patients was (98.54±16.93) g/L. Among them, hemoglobin ranged in 110-120 g/L in 28 cases, accounting for 22%. Pearson correlation analysis showed that hemoglobin was significantly positively correlated with leukocyte (r=0.279, P=0.001), erythrocrit (r=0.279, P=0.002), serum iron (r=0.188, P=0.033) and dialysis adequacy (r=0.215, P=0.015), but negative with hepcidin (r=-0.302, P=0.001), serum ferritin (r=-0.207, P=0.019), UIBC (r=-0.195, P=0.027), iPTH (r=-0.264, P=0.003) and C reaction protein (r=-0.203, P=0.022). Multiple linear stepwise regression model results suggested that the hemoglobin protein was positively correlated with erythrocrit (P<0.01), but negatively with hepcidin (P=0.001) and iPTH (P<0.05).Conclusions Anemia in MHD patients is closely related with number of white blood cells, hematocrit, hepcidin, serum iron, dialysis adequacy, UIBC, iPTH, C reaction protein, serum iron and other factors, Little correlation with folic acid and vitamin B12.